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Title: Monochromatic computed microtomography using laboratory and synchrotron sources and X-ray fluorescence analysis for comprehensive analysis of structural changes in bones
Authors: Buzmakov, Alexey
Chukalina, Marina
Nikolaev, Dmitry
Gulimova, Victoriya
Savel'ev, Sergey
Tereschenko, Elena
Seregin, Alexey
Senin, Roman
Zolotov, Denis
Prun, Victor
Shaefer, Gerald
Asadchikov, Victor
Keywords: Monochromatic computed microtomography
X-ray fluorescence analysis
Bone
Issue Date: 2015
Publisher: International Union of Crystallography
Citation: BUZMAKOV, A. ... et al, 2015. Monochromatic computed microtomography using laboratory and synchrotron sources and X-ray fluorescence analysis for comprehensive analysis of structural changes in bones. Journal of Applied Crystallography, 48, pp. 693 - 701.
Abstract: A combination of X-ray tomography at different wavelengths and X-ray fluorescence analysis was applied in the study of two types of bone tissue changes: prolonged presence in microgravity conditions and age-related bone growth. The proximal tail vertebrae of geckos were selected for investigation because they do not bear the supporting load in locomotion, which allows them to be considered as an independent indicator of gravitational influence. For the vertebrae of geckos no significant differences were revealed in the elemental composition of the flight samples and the synchronous control samples. In addition, the gecko bone tissue samples from the jaw apparatus, spine and shoulder girdle were measured. The dynamics of structural changes in the bone tissue growth was studied using samples of a human fetal hand. The hands of human fetuses of 11–15 weeks were studied. Autonomous zones of calcium accumulation were found not only in individual fingers but in each of the investigated phalanges. The results obtained are discussed.
Description: This is an Open Access article published by the International Union of Crystallography and distributed under the terms of the Creative Commons Attribution Licence.
Sponsor: This study was supported by the grants of the RFBR 13-02- 00552, 13-07-00970, 13-07-12179 and by the Russian Ministry of Education and Science (agreement No. 14.616.21.0005). The investigations were partially performed using the equipment of the Shared Research Center of the Shubnikov Institute of Crystallography RAS and were supported by the Russian Ministry of Education and Science (project RFMEFI62114X0005), and the Mixed-Use Center of the Kurchatov Center of Synchrotron Radiation and Nanotechnologies (state contract No. 16.552.11.7003).
Version: Published
DOI: 10.1107/S1600576715006214
URI: https://dspace.lboro.ac.uk/2134/18491
Publisher Link: http://dx.doi.org/10.1107/S1600576715006214
ISSN: 0021-8898
Appears in Collections:Published Articles (Computer Science)

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