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|Title: ||Positive and negative allosteric effects of thiacalixarene-based receptors having urea and crown-ether moieties|
|Authors: ||Tomiyasu, Hirotsugu|
Elsegood, Mark R.J.
Teat, Simon J.
|Issue Date: ||2015|
|Publisher: ||© The Royal Society of Chemistry|
|Citation: ||TOMIYASU, H. ...et al., 2015. Positive and negative allosteric effects of thiacalixarene-based receptors having urea and crown-ether moieties. RSC ADVANCES, 5(19), pp.14747-14755.|
|Abstract: ||Heteroditopic receptors (4a~e) based on a thiacalixarene in the 1,3-alternate conformation, which have two urea moieties linking various phenyl groups substituted with either electron-donating or -withdrawing groups at their m-, or p-positions with a crown-ether moiety at the opposite side of thiacalixarene cavity, have been synthesized. The two examples with p-CH3- (4b) and p-NO2-substituted (4e) (phenyl groups have been characterized by X-ray crystallography. The binding property of receptors 4e was investigated by means of 1H NMR spectroscopic and absorption titration experiments in CHCl3–DMSO (10:1, v/v) solution in the presence of K+ ion and various anions. Interestingly, it was found that receptor 4e, which possesses two p-nitrophenyl ureido moieties, can complex most efficiently in the urea cavity or the crown-ether moiety; and the plausible allosteric effect of receptor 4e was also studied.|
|Description: ||This paper was published as Open Access under a Creative Commons Attribution 3.0 Unported Licence.|
|Sponsor: ||The authors acknowledge financial and logistic support from
the Flemish Research Foundation (FWO). Stijn Van Malderen is
a PhD fellow of the FWO. Amy Managh acknowledges financial
support through a Loughborough University Enterprise
Fellowship (Engineering and Physical Sciences Research
Council, Impact Acceleration Account).|
|Publisher Link: ||http://dx.doi.org/10.1039/c4ra15905e|
|Appears in Collections:||Published Articles (Chemistry)|
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