BUTLER, S.J. ... et al, 2014. EuroTracker dyes: highly emissive europium complexes as alternative organelle stains for live cell imaging. Chemical Science, 5 (5), pp. 1750 - 1756.
Nine very bright europium(III) complexes with different macrocyclic ligands have been prepared that exhibit
excellent cell uptake behaviour and distinctive sub-cellular localisation profiles, allowing the use of
fluorescence microscopy and time-gated spectral imaging to track their fate in cellulo. Their use as
cellular imaging stains is described for the selective illumination of mitochondria, lysosomes or the
endoplasmic reticulum of various mammalian cell types.
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We thank the ERC for support (DP, SJB, RP; FCC 266804).