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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/18713

Title: Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes
Authors: Imbrogno, A.
Dragosavac, Marijana M.
Piacentini, Emma
Vladisavljevic, Goran T.
Holdich, R.G.
Giorno, L.
Keywords: Membrane emulsification scale up
W/O/W emulsion
Uniform spherical microcapsules
High encapsulation efficiency
Vitamin E
Issue Date: 2015
Publisher: © Elsevier
Citation: IMBROGNO, A. ...et al., 2015. Polycaprolactone multicore-matrix particle for the simultaneous encapsulation of hydrophilic and hydrophobic compounds produced by membrane emulsification and solvent diffusion processes. Colloids and Surfaces B: Biointerfaces, Vol 135, pp. 116-125
Abstract: Co-encapsulation of drugs in the same carrier, as well as the development of microencapsulation processes for biomolecules using mild operating conditions, and the production of particles with tailored size and uniformity are major challenges for encapsulation technologies. In the present work, a suitable method consisting of the combination of membrane emulsification with solvent diffusion is reported for the production of multi-core matrix particles with tailored size and potential application in multi-therapies. In the emulsification step, the production of a W/O/W emulsion was carried out using a batch Dispersion Cell for formulation testing and subsequently a continuous azimuthally oscillating membrane emulsification system for the scaling-up of the process to higher capacities. In both cases precise and gentle control of droplet size and uniformity of the W/O/W emulsion was achieved, preserving the encapsulation of the drug model within the droplet. Multi-core matrix particles were produced in a post emulsification step using solvent diffusion. The compartmentalized structure of the multicore-matrix particle combined with the different chemical properties of polycaprolactone (matrix material) and fish gelatin (core material) was tested for the simultaneous encapsulation of hydrophilic (copper ions) and hydrophobic (α-tocopherol) test components. The best operating conditions for the solidification of the particles to achieve the highest encapsulation efficiency of copper ions and α-tocopherol of 99 (±4)% and 93(±6)% respectively were found. The multi-core matrix particle produced in this work demonstrates good potential as a co-loaded delivery system.
Description: This paper was accepted for publication in the journal Colloids and Surfaces B: Biointerfaces and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfb.2015.06.071
Sponsor: The authors gratefully acknowledge the financial support of PON OLIO PIU' 01_545.
Version: Accepted for publication
DOI: 10.1016/j.colsurfb.2015.06.071
URI: https://dspace.lboro.ac.uk/2134/18713
Publisher Link: http://dx.doi.org/10.1016/j.colsurfb.2015.06.071
ISSN: 1873-4367
Appears in Collections:Published Articles (Chemical Engineering)

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