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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/18764

Title: Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes
Authors: Gempf, Kathryn L.
Butler, Stephen J.
Funk, Alexander M.
Parker, David
Issue Date: 2013
Publisher: © The Royal Society of Chemistry
Citation: GEMPF, K.L. ... et al, 2013. Direct and selective tagging of cysteine residues in peptides and proteins with 4-nitropyridyl lanthanide complexes. Chemical Communications, 49 (80), pp. 9104 - 9106.
Abstract: A cysteine-selective tagging method in water is reported, based on rapid displacement of a pyridyl nitro-substituent in simple pyridines and lanthanide complexes. The conjugation reaction creates a short link between the tag and peptide, holding the peptide closer to the Ln3+ ion and with reduced flexibility compared to existing methods.
Description: This article is closed access.
Sponsor: We thank the ERC for support (FCC 266804).
Version: Published
DOI: 10.1039/c3cc45875j
URI: https://dspace.lboro.ac.uk/2134/18764
Publisher Link: http://dx.doi.org/10.1039/c3cc45875j
ISSN: 1359-7345
Appears in Collections:Closed Access (Chemistry)

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