Suhaimi&Das_BILE_Sept2015_Final copy.pdf (1.01 MB)
Glucose diffusivity in cell-seeded tissue engineering scaffolds
journal contribution
posted on 2015-09-16, 15:35 authored by Hazwani Suhaimi, Diganta DasDiganta DasObjective: A series of well-defined diffusion experiments was carried out to determine the effective glucose diffusion coefficient in cell-seeded porous scaffolds to understand the importance of nutrient diffusion in tissue engineering bioreactor.
Results Cell growth changed the morphological structure of the scaffolds reducing the effective pore space and inevitably decreased the effective glucose diffusivity in the chosen scaffolds, namely, collagen, poly(L-lactide) and poly(caprolactone) scaffolds from 3.71 x 10-9 m2/s to 3.23 x 10-9 m2/s, 1.39 x 10-10 m2/s to 9.09 x 10-11 m2/s and 1.78 x 10-10 m2/s to 1.32 x 10-10 m2/s, respectively.
Conclusions The presence of cells over time during cell culture reduces the mobility of glucose. The results of this study should be possible to use to predict the glucose concentration profiles in thick engineered tissues.
History
School
- Aeronautical, Automotive, Chemical and Materials Engineering
Department
- Chemical Engineering
Published in
Biotechnology LettersCitation
SUHAIMI, H. and DAS, D.B., 2016. Glucose diffusivity in cell-seeded tissue engineering scaffolds. Biotechnology Letters, 38(1), pp.183-190.Publisher
© Springer Science+Business Media DordrechtVersion
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2016Notes
The final publication is available at Springer via http://dx.doi.org/10.1007/s10529-015-1958-2ISSN
0141-5492eISSN
1573-6776Publisher version
Language
- en