Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/18782

Title: Glucose diffusivity in cell-seeded tissue engineering scaffolds
Authors: Suhaimi, Hazwani
Das, Diganta Bhusan
Keywords: Diffusion coefficient
Osteoblast cell
Tissue engineering
Issue Date: 2016
Publisher: © Springer Science+Business Media Dordrecht
Citation: SUHAIMI, H. and DAS, D.B., 2016. Glucose diffusivity in cell-seeded tissue engineering scaffolds. Biotechnology Letters, 38(1), pp.183-190.
Abstract: Objective: A series of well-defined diffusion experiments was carried out to determine the effective glucose diffusion coefficient in cell-seeded porous scaffolds to understand the importance of nutrient diffusion in tissue engineering bioreactor. Results Cell growth changed the morphological structure of the scaffolds reducing the effective pore space and inevitably decreased the effective glucose diffusivity in the chosen scaffolds, namely, collagen, poly(L-lactide) and poly(caprolactone) scaffolds from 3.71 x 10-9 m2/s to 3.23 x 10-9 m2/s, 1.39 x 10-10 m2/s to 9.09 x 10-11 m2/s and 1.78 x 10-10 m2/s to 1.32 x 10-10 m2/s, respectively. Conclusions The presence of cells over time during cell culture reduces the mobility of glucose. The results of this study should be possible to use to predict the glucose concentration profiles in thick engineered tissues.
Description: The final publication is available at Springer via http://dx.doi.org/10.1007/s10529-015-1958-2
Version: Accepted for publication
DOI: 10.1007/s10529-015-1958-2
URI: https://dspace.lboro.ac.uk/2134/18782
Publisher Link: http://dx.doi.org/10.1007/s10529-015-1958-2
ISSN: 0141-5492
Appears in Collections:Published Articles (Chemical Engineering)

Files associated with this item:

File Description SizeFormat
Suhaimi&Das_BILE_Sept2015_Final copy.pdfAccepted version1.03 MBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.