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Title: Using the cost-effectiveness of allogeneic islet transplantation to inform iPSC derived beta cell therapy reimbursement
Authors: Archibald, Peter R.T.
Williams, David J.
Keywords: Reimbursement
Induced pluripotent stem cell
Beta cell
Allogeneic islet transplantation
Incremental cost-effectiveness ratio
Quality-adjusted life years
Issue Date: 2015
Publisher: Future Medicine / © The Authors
Citation: ARCHIBALD, P.R.T. and WILLIAMS, D.J., 2015. Using the cost-effectiveness of allogeneic islet transplantation to inform iPSC derived beta cell therapy reimbursement. Regenerative Medicine, 10 (8), pp. 959-973.
Abstract: In the present study a cost-effectiveness analysis of Allogeneic Islet Transplantation was performed and the financial feasibility of a Human Induced Pluripotent Stem Cell (hiPSC) derived Beta Cell therapy was explored. Previously published cost and health benefit data for Islet Transplantation was utilised to perform the cost-effectiveness and sensitivity analyses. It was determined that, over a 9 year time horizon, Islet Transplantation would become cost saving and ‘dominate’ the comparator. Over a 20 year time horizon, Islet Transplantation would incur significant cost savings over the comparator (£59,000). Finally, assuming a similar cost of goods to Islet Transplantation and a lack of requirement for immunosuppression, a hiPSC-derived Beta Cell therapy would dominate the comparator over an 8 year time horizon.
Description: This is an Open Access article published by Future Medicine and licensed under a Creative Commons Attribution 4.0 Unported License
Sponsor: This research was funded by Loughborough University and the Engineering and Physical Sciences Research Council (EPSRC).
Version: Published.
DOI: 10.2217/rme.15.59
URI: https://dspace.lboro.ac.uk/2134/18894
Publisher Link: http://dx.doi.org/10.2217/rme.15.59
ISSN: 1746-076X
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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