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Title: Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study-NIDCVD-2
Authors: Bhatti, Gurjit Kaur
Bhadada, Sanjay Kumar
Vijayvergiya, Rajesh
Mastana, Sarabjit S.
Bhatti, Jasvinder Singh
Keywords: Metabolic syndrome
Harmonized criteria of metabolic syndrome
Type 2 diabetes
CAD
Asian Indians
Issue Date: 2016
Publisher: © Elsevier
Citation: BHATTI, G.K. ... et al, 2016. Metabolic syndrome and risk of major coronary events among the urban diabetic patients: North Indian Diabetes and Cardiovascular Disease Study-NIDCVD-2. Journal of Diabetes and its Complications, 30(1), pp.72-78.
Abstract: Objective: The present study aimed at estimating the prevalence of metabolic syndrome (MetS) and prospectively, evaluating cardiovascular events among Asian Indians type 2 diabetic subjects. Methods: The sample comprised 1522 type 2 diabetic mellitus (T2DM) subjects aged 25-91. years, who participated in the North Indian Diabetes and Cardiovascular Disease Study (NIDCVD). The participants were screened for hypertension, dyslipidemia, obesity and cardiovascular events. Anthropometric, clinical and biochemical measurements were done in all subjects. The prevalence of MetS was estimated in all the subjects according to the harmonized criteria of 2009. Results: The prevalence of MetS among urban Indian diabetic subjects was 71.9% and was significantly higher in females (86%) as compared to males (57.9%). To determine the independent predictors of the MetS in diabetic sample, binary logistic regression analyses were performed using demographic and biochemical parameters. Significant differences in the indices of generalized and abdominal obesity and lipids (total cholesterol, high density lipoprotein) were observed (p <. 0.01) in male:female and MetS and non-MetS comparisons. Regression analysis for prediction of CAD showed that family history, age, body mass index (BMI), SBP, physical inactivity and hypertension independently and significantly predicted the disease outcome. Binary logistic regression analysis revealed that MetS may be an independent risk/predictor of CAD (odd ratio (OR) = 3.44, CI 1.31-9.01, p = 0.012) along with higher age groups, BMI and hypertension in Indian population. Conclusion: The study demonstrated that the high prevalence of MetS and its different components were positively associated with a higher risk of CAD in north Indian diabetic subjects. Nevertheless, MetS is a major health problem in India, comprehensive population studies are warranted for estimation of incidence and prevalence, and education should be provided on its prevention and control to reduce the diabetes-related morbidity and mortality.
Description: This paper was accepted for publication in the journal Journal of Diabetes and its Complications and the definitive published version is available at http://dx.doi.org/10.1016/j.jdiacomp.2015.07.008
Sponsor: The authors are grateful to University Grant Commission, New Delhi for providing financial assistance to carry out the present work.
Version: Accepted for publication
DOI: 10.1016/j.jdiacomp.2015.07.008
URI: https://dspace.lboro.ac.uk/2134/18896
Publisher Link: http://dx.doi.org/10.1016/j.jdiacomp.2015.07.008
ISSN: 1056-8727
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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