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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/18923

Title: Detection and quantification of beta-amyloid, pyroglutamyl A beta, and tau in aged canines
Authors: Schmidt, F.
Boltze, J.
Jager, C.
Hofmann, S.
Willems, N.
Seeger, J.
Hartig, W.
Stolzing, Alexandra
Keywords: Alzheimer's Disease
Neurofibrillary tangles
Diffuse plaques
Senile plaques
Issue Date: 2015
Publisher: © The American Association of Neuropathologists. Published by Oxford Univ. Press.
Citation: SCHMIDT, F. ...et al., 2015. Detection and quantification of beta-amyloid, pyroglutamyl A beta, and tau in aged canines. Journal of Neuropathology and Experimental Neurology, 74 (9), pp. 912 - 923
Abstract: Canine cognitive dysfunction syndrome is an age-associated disorder that resembles many aspects of human Alzheimer disease. The characterization of canine cognitive dysfunction syndrome has been restricted to selected laboratory dogs and mongrels, thereby limiting our knowledge of potential breed-related and age-related differences. We examined the brains of 24 dogs from various breeds. The frontal cortex, hippocampus, and entorhinal cortex were investigated. Deposits of β-amyloid (Aβ) and tau were analyzed phenotypically and quantified stereologically. In all dogs aged 10 years or older, plaques containing pyroglutamyl Aβ and Aβ8–17 were detected. Within the ventral hippocampus, significantly more pyroglutamyl Aβ plaques were deposited in small and medium dogs than in large dogs. Hyperphosphorylated tau with formation of neurofibrillary tangles was observed in 3 animals aged 13 to 15 years. This study provides the first investigation of pyroglutamyl Aβ in comparison with total Aβ (as shown by Aβ8–17 immunoreactivity) in dogs of different breeds, sizes, and ages. Our results indicate that canine cognitive dysfunction syndrome is relatively common among aged canines, thereby emphasizing the relevance of such populations to translational Alzheimer disease research.
Description: This is in closed access.
Version: Accepted for publication
DOI: 10.1097/NEN.0000000000000230
URI: https://dspace.lboro.ac.uk/2134/18923
Publisher Link: http://dx.doi.org/10.1097/NEN.0000000000000230
ISSN: 0022-3069
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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