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|Title: ||Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women|
|Authors: ||Endrighi, Romano|
Hackett, Ruth A.
Carvalho, Livia A.
Jackson, Sarah E.
|Issue Date: ||2015|
|Publisher: ||© The Author(s). Published by Taylor and Francis.|
|Citation: ||ENDRIGHI, R. ... et al., 2015. Effect of short-term weight loss on mental stress-induced cardiovascular and pro-inflammatory responses in women. Stress: the International Journal on the Biology of Stress, 18 (5), pp. 602-606.|
|Abstract: ||Epidemiologic evidence links psychosocial stress with obesity but experimental studies
examining the mechanisms that mediates the effect of stress on adiposity are scarce. The aim of
this study was to investigate whether changes in adiposity following minimal weight loss affect
heightened stress responses in women, and examine the role of the adipokine leptin in driving
inflammatory responses. Twenty-three overweight or obese, but otherwise healthy, women
(M age ¼ 30.41 ± 8.0 years; BMI ¼ 31.9 ± 4.1 kg/m2
) completed standardized acute mental stress
before and after a 9-week calorie restriction program designed to modify adiposity levels.
Cardiovascular (blood pressure and heart rate) and inflammatory cytokines (leptin and
interleukin-6; IL-6) responses to mental stress were assessed several times between baseline
and a 45-min post-stress recovery period. There were modest changes in adiposity measures
while the adipokine leptin was markedly reduced (27%) after the intervention. Blood pressure
reactivity was attenuated (3.38 ± 1.39 mmHg) and heart rate recovery was improved
(2.07 ± 0.96 Bpm) after weight loss. Blood pressure responses were inversely associated with
changes in waist to hip ratio post intervention. Decreased levels of circulating leptin following
weight loss were inversely associated with the IL-6 inflammatory response to stress (r ¼ 0.47).
We offered preliminary evidence suggesting that modest changes in adiposity following a brief
caloric restriction program may yield beneficial effect on cardiovascular stress responses. In
addition, reductions in basal leptin activity might be important in blunting pro-inflammatory
responses. Large randomized trials of the effect of adiposity on autonomic responses are thus
|Description: ||This is an Open Access article distributed under the terms of the
Creative Commons Attribution License (http://creativecommons.org/
Licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided the original work is properly
|Sponsor: ||This research was
funded by the British Heart Foundation.|
|Publisher Link: ||http://dx.doi.org/10.3109/10253890.2015.1064889|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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