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|Title: ||Disruption of multisystem responses to stress in type 2 diabetes: investigating the dynamics of allostatic load|
|Authors: ||Steptoe, Andrew|
Hackett, Ruth A.
Lazzarino, Antonio I.
La Marca, Roberto
Carvalho, Livia A.
|Issue Date: ||2014|
|Publisher: ||© The Authors. Published by the National Academy of Sciences.|
|Citation: ||STEPTOE, A. ... et al., 2014. Disruption of multisystem responses to stress in type 2 diabetes: investigating the dynamics of allostatic load. Proceedings of the National Academy of Sciences, 111 (44), pp. 15693–15698.|
|Abstract: ||Psychological stress-related processes are thought to contribute
to the development and progression of type 2 diabetes, but the
biological mechanisms involved are poorly understood. Here, we
tested the notion that people with type 2 diabetes experience
chronic allostatic load, manifest as dynamic disturbances in reactivity
to and recovery from stress across multiple (cardiovascular, neuroendocrine,
inflammatory, metabolic) biological systems, coupled
with heightened experience of chronic life stress. We carried out
an experimental comparison of 140 men and women aged 50–75 y
with type 2 diabetes and 280 nondiabetic individuals matched on
age, sex, and income. We monitored blood pressure (BP) and heart
rate, salivary cortisol, plasma interleukin (IL)-6, and total cholesterol
in response to standardized mental stress, and assessed salivary cortisol
over the day. People with type 2 diabetes showed impaired
poststress recovery in systolic and diastolic BP, heart rate and cholesterol,
and blunted stress reactivity in systolic BP, cortisol, cholesterol,
and IL-6. Cortisol and IL-6 concentrations were elevated, and
cortisol measured over the day was higher in the type 2 diabetes
group. Diabetic persons reported greater depressive and hostile
symptoms and greater stress experience than did healthy controls.
Type 2 diabetes is characterized by disruption of stress-related processes
across multiple biological systems and increased exposure to
life stress. Chronic allostatic load provides a unifying perspective
with implications for etiology and patient management.|
|Description: ||Closed access. This article is also available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226108/|
|Sponsor: ||This study was supported by the British Heart Foundation
|Publisher Link: ||http://dx.doi.org/10.1073/pnas.1410401111|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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