Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/19185

Title: Job strain and the risk of stroke: an individual-participant data meta-analysis
Authors: Fransson, Eleonor I.
Nyberg, Solja T.
Heikkila, Katriina
Hamer, Mark
Keywords: Psychological
Issue Date: 2015
Publisher: © American Heart Association, Inc.
Citation: FRANSSON, E.I. ... et al., 2015. Job strain and the risk of stroke: an individual-participant data meta-analysis. Stroke, 46 (2), pp. 557-559.
Abstract: Background and Purpose—Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain. Methods—We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke. Results—In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status. Conclusion—Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.
Description: The authors are: Eleonor I. Fransson, PhD; Solja T. Nyberg, MSc; Katriina Heikkilä, PhD; Lars Alfredsson, PhD; Jakob B. Bjorner, MD, PhD; Marianne Borritz, MD, PhD; Hermann Burr, PhD; Nico Dragano, PhD; Goedele A. Geuskens, PhD; Marcel Goldberg, MD, PhD; Mark Hamer, PhD; Wendela E. Hooftman, PhD; Irene L. Houtman, PhD; Matti Joensuu, MSc; Markus Jokela, PhD; Anders Knutsson, PhD; Markku Koskenvuo, MD, PhD; Aki Koskinen, MSc; Meena Kumari, PhD; Constanze Leineweber, PhD; Thorsten Lunau, MSc; Ida E.H. Madsen, PhD; Linda L. Magnusson Hanson, PhD; Martin L. Nielsen, MD, PhD; Maria Nordin, PhD; Tuula Oksanen, MD, PhD; Jaana Pentti, BSc; Jan H. Pejtersen, PhD; Reiner Rugulies, PhD; Paula Salo, PhD; Martin J. Shipley, MSc; Andrew Steptoe, DPh; Sakari B. Suominen, MD, PhD; Töres Theorell, MD, PhD; Salla Toppinen-Tanner, PhD; Jussi Vahtera, MD, PhD; Marianna Virtanen, PhD; Ari Väänänen, PhD; Peter J.M. Westerholm, MD, PhD; Hugo Westerlund, PhD; Marie Zins, MD, PhD; Annie Britton, PhD; Eric J. Brunner, PhD; Archana Singh-Manoux, PhD; G. David Batty, PhD; Mika Kivimäki, PhD. This article was published in the journal, Stroke [© American Heart Association, Inc.] and the definitive version is available at: http://stroke.ahajournals.org/content/46/2/557
Sponsor: Funding for the IPD-Work Consortium
Version: Accepted for publication
DOI: 10.1161/STROKEAHA.114.008019
URI: https://dspace.lboro.ac.uk/2134/19185
Publisher Link: http://dx.doi.org/10.1161/STROKEAHA.114.008019
ISSN: 1524-4628
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

Files associated with this item:

File Description SizeFormat
work stress _ stroke IPD [Stroke].pdfAccepted version184.22 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.