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Title: Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study
Authors: Akbaraly, Tasnime N.
Shipley, Martin J.
Ferrie, Jane E.
Virtanen, Marianna
Lowe, Gordon
Hamer, Mark
Kivimaki, Mika
Keywords: Prospective cohort
Nutritional epidemiology
Alternative healthy eating index
Diet quality indices
Inflammatory marker
Middle-aged population
Issue Date: 2014
Publisher: © The Authors. Published by Elsevier Inc.
Citation: AKBARALY, T.N. ... et al., 2014. Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study. American Journal of Medicine, 128 (2), pp. 152–160.e4
Abstract: BACKGROUND: Inflammation plays an important role in the cause of cardiovascular diseases and may contribute to the association linking an unhealthy diet to chronic age-related diseases. However, to date the long-term associations between diet and inflammation have been poorly described. Our aim was to assess the extent to which adherence to a healthy diet and dietary improvements over a 6-year exposure period prevented subsequent chronic inflammation over a 5-year follow-up in a large British population of men and women. METHODS: Data were drawn from 4600 adults (mean standard deviation, age 49.6 6.1 years, 28% were women) from the prospective Whitehall cohort II study. Adherence to a healthy diet was measured using Alternative Healthy Eating Index (AHEI) scores in 1991-1993 (50.7 11.9 points) and 1997-1999 (51.6 12.4 points). Chronic inflammation, defined as average levels of serum interleukin-6 from 2 measures 5 years apart, was assessed in 1997-1999 and 2002-2004. RESULTS: After adjustment for sociodemographic factors, health behaviors, and health status, participants who maintained a high AHEI score (ie, a healthy diet, n ¼ 1736, 37.7%) and those who improved this score over time (n ¼ 681, 14.8%) showed significantly lower mean levels of interleukin-6 (1.84 pg/mL, 95% confidence interval [CI], 1.71-1.98 and 1.84 pg/mL, 95% CI, 1.70-1.99, respectively) than those who had a low AHEI score (n ¼ 1594, 34.6%) over the 6-year exposure period (2.01 pg/mL, 95% CI, 1.87-2.17). CONCLUSIONS: These data suggest that maintaining and improving adherence to healthy dietary recommendations may reduce the risk of long-term inflammation.
Description: This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
Sponsor: The Whitehall II study is supported by grants from the British Medical Research Council (MR/K013351/1); the British Heart Foundation (PG/11/63/29011 and RG/13/2/30098); the Economic and Social Research Council (ES/J023299/1); the National Heart, Lung, and Blood Institute (R01HL036310); the National Institute on Aging, National Institutes of Health (R01AG013196 and R01AG034454); and the Agency for Health Care Policy and Research (Grant HS06516). TA is supported by the Economic and Social Research Council (ES/J023299/1), the National Institutes of Health and by the Languedoc-Roussillon Region (Chercheur d’avenir Grant 2011). MJS is partly supported by the British Heart Foundation. MK is supported by the Medical Research Council (MR/K013351/1), the British Heart Foundation (PG/11/63/29011 and RG/13/2/30098), Academy of Finland, and a professorial fellowship from the Economic and Social Research Council (ES/ J023299/1).
Version: Published
DOI: 10.1016/j.amjmed.2014.10.002
URI: https://dspace.lboro.ac.uk/2134/19186
Publisher Link: http://dx.doi.org/10.1016/j.amjmed.2014.10.002
ISSN: 1555-7162
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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