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|Title: ||Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study|
|Authors: ||Hamer, Mark|
Batty, G. David
Shipley, Martin J.
Tabak, Adam G.
|Keywords: ||C-reactive protein|
|Issue Date: ||2012|
|Publisher: ||© American Heart Association|
|Citation: ||HAMER, M. ...et al., 2012. Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study. Circulation, 126, pp. 928-933.|
|Abstract: ||Background—Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical
activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term
prospective data are available. We therefore examined the association between physical activity and inflammatory
markers over a 10-year follow-up period.
Methods and Results—Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study.
Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6)
were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard
physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all
assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this
difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines
over the 10-year follow-up, the high-adherence group displayed lower loge C-reactive protein ( 0.07; 95%
confidence interval, 0.12 to 0.02) and loge interleukin-6 ( 0.07; 95% confidence interval, 0.10 to 0.03) at
follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who
reported an increase in physical activity of at least 2.5 h/wk displayed lower loge C-reactive protein ( coefficient
0.05; 95% confidence interval, 0.10 to 0.001) and loge interleukin-6 ( coefficient 0.06; 95%
confidence interval, 0.09 to 0.03) at follow-up.
Conclusions—Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and
thus may be important in preventing the proinflammatory state seen with aging.|
|Description: ||This paper is in closed access.|
|Sponsor: ||The Whitehall II study has been supported by grants from the Medical Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart, Lung, and Blood Institute (R01HL36310), US National Institutes of Health [NIH]; National Institute on Aging (R01AG013196; R01AG034454), NIH; Agency
for Health Care Policy Research (HS06516); and the John D. and Catherine T. MacArthur Foundation Research Networks on Successful
Midlife Development and Socio-economic Status and Health.|
|Publisher Link: ||http://dx.doi.org/10.1161/CIRCULATIONAHA.112.103879|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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