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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/19196

Title: Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study
Authors: Hamer, Mark
Sabia, Severine
Batty, G. David
Shipley, Martin J.
Tabak, Adam G.
Singh-Manoux, Archana
Kivimaki, Mika
Keywords: C-reactive protein
Issue Date: 2012
Publisher: © American Heart Association
Citation: HAMER, M. ...et al., 2012. Physical activity and inflammatory markers over 10 years: follow-up in men and women from the Whitehall II cohort study. Circulation, 126, pp. 928-933.
Abstract: Background—Inflammatory processes are putative mechanisms underlying the cardioprotective effects of physical activity. An inverse association between physical activity and inflammation has been demonstrated, but no long-term prospective data are available. We therefore examined the association between physical activity and inflammatory markers over a 10-year follow-up period. Methods and Results—Participants were 4289 men and women (mean age, 49.2 years) from the Whitehall II cohort study. Self-reported physical activity and inflammatory markers (serum high-sensitivity C-reactive protein and interleukin-6) were measured at baseline (1991) and follow-up (2002). Forty-nine percent of the participants adhered to standard physical activity recommendations for cardiovascular health (2.5 h/wk moderate to vigorous physical activity) across all assessments. Physically active participants at baseline had lower C-reactive protein and interleukin-6 levels, and this difference remained stable over time. Compared with participants who rarely adhered to physical activity guidelines over the 10-year follow-up, the high-adherence group displayed lower loge C-reactive protein ( 0.07; 95% confidence interval, 0.12 to 0.02) and loge interleukin-6 ( 0.07; 95% confidence interval, 0.10 to 0.03) at follow-up after adjustment for a range of covariates. Compared with participants who remained stable, those who reported an increase in physical activity of at least 2.5 h/wk displayed lower loge C-reactive protein ( coefficient 0.05; 95% confidence interval, 0.10 to 0.001) and loge interleukin-6 ( coefficient 0.06; 95% confidence interval, 0.09 to 0.03) at follow-up. Conclusions—Regular physical activity is associated with lower markers of inflammation over 10 years of follow-up and thus may be important in preventing the proinflammatory state seen with aging.
Description: This paper is in closed access.
Sponsor: The Whitehall II study has been supported by grants from the Medical Research Council; British Heart Foundation; Health and Safety Executive; Department of Health; National Heart, Lung, and Blood Institute (R01HL36310), US National Institutes of Health [NIH]; National Institute on Aging (R01AG013196; R01AG034454), NIH; Agency for Health Care Policy Research (HS06516); and the John D. and Catherine T. MacArthur Foundation Research Networks on Successful Midlife Development and Socio-economic Status and Health.
Version: Published
DOI: 10.1161/CIRCULATIONAHA.112.103879
URI: https://dspace.lboro.ac.uk/2134/19196
Publisher Link: http://dx.doi.org/10.1161/CIRCULATIONAHA.112.103879
ISSN: 0009-7322
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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