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|Title: ||Sarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing|
|Authors: ||Hamer, Mark|
Batty, G. David
|Issue Date: ||2015|
|Publisher: ||Macmillan Publishers Limited (Nature Publishing Group)|
|Citation: ||HAMER, M., BATTY, G.D. and KIVIMAKI, M., 2015. Sarcopenic obesity and risk of new onset depressive symptoms in older adults: English Longitudinal Study of Ageing. International Journal of Obesity, advance online publication 8 September 2015; doi: 10.1038/ijo.2015.124|
|Abstract: ||Background: We examined the role of sarcopenic obesity as a risk factor for new-onset depressive symptoms over 6-year follow-up in a large sample of older adults.
Methods: The sample comprised 3862 community dwelling participants (1779 men, 2083 women; mean age 64.6±8.3 years) without depressive symptoms at baseline, recruited from the English Longitudinal Study of Ageing. At baseline and 4-year follow-up, handgrip strength (kg) of the dominant hand was assessed using a hand-held dynamometer, as a measure of sarcopenia. The outcome was new onset depressive symptoms at 6-year follow-up, defined as a score of greater than or equal to4 on the 8-item Centre of Epidemiological Studies Depression scale. Sarcopenic obesity was defined as obese individuals (body mass index greater than or equal to30 kg m−2) in the lowest tertile of sex-specific grip strength (<35.3 kg men; <19.6 kg women).
Results: Using a multivariable logistic regression model, the risk of depressive symptoms was greatest in obese adults in the lowest tertile of handgrip strength (odds ratio (OR), 1.79, 95% confidence interval (CI), 1.10, 2.89) compared with non-obese individuals with high handgrip strength. Participants who were obese at baseline and had a decrease of more than 1 s.d. in grip strength over 4-year follow-up were at greatest risk of depressive symptoms (OR=1.97, 95% CI, 1.22, 3.17) compared with non-obese with stable grip strength.
Conclusions: A reduction in grip strength was associated with higher risk of depressive symptoms in obese participants only, suggesting that sarcopenic obesity is a risk factor for depressive symptoms.|
|Description: ||This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.|
|Sponsor: ||The funding is provided by the National Institute on Aging in the United States (grants 2RO1AG7644-01A1 and 2RO1AG017644) and a consortium of UK government departments coordinated by the Office for National Statistics. MH is supported by the British Heart Foundation (RE/10/005/28296); MK by the Medical Research Council (K013351) and the Economic and Social Research Council.|
|Publisher Link: ||http://dx.doi.org/10.1038/ijo.2015.124|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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