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|Title: ||The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults|
|Authors: ||Lazzarino, Antonio I.|
|Issue Date: ||2013|
|Publisher: ||© Elsevier|
|Citation: ||LAZZARINO, A.I. ... et al., 2013. The association between cortisol response to mental stress and high-sensitivity cardiac troponin T plasma concentration in healthy adults. Journal of the American College of Cardiology, 62(18), pp. 1694–1701.|
|Abstract: ||Objectives The objective of this study was to examine the association between cortisol response to mental stress and highsensitivity
cardiac troponin T (hs-cTnT) in healthy older individuals without history of cardiovascular disease (CVD).
Background Mental stress is a recognized risk factor for CVD, although the mechanisms remain unclear. Cortisol, a key stress
hormone, is associated with coronary atherosclerosis and may accentuate structural and functional cardiac disease.
Methods This cross-sectional study involved 508 disease-free men and women aged 53 to 76 years drawn from the Whitehall II epidemiological cohort. We evaluated salivary cortisol response to standardized mental stress tests (exposure) and
hs-cTnT plasma concentration using a high-sensitivity assay (outcome). We measured coronary calcification using
electron-beam dual-source computed tomography and Agatston scores.
Results After adjustment for demographic and clinical variables associated withCVDaswell as for inflammatory factors,wefound
a robust association between cortisol response and detectable hs-cTnT (odds ratio [OR]: 3.98; 95% confidence interval
[CI]: 1.60 to 9.92; p¼ 0.003). The association remained when we restricted the analysis to participants without coronary
calcification (n¼222; OR: 4.77; 95%CI: 1.22 to 18.72; p¼0.025) or when we further adjusted for coronary calcification
in participants with positive Agatston scores (n ¼ 286; OR: 7.39; 95% CI: 2.22 to 26.24; p ¼ 0.001).
Conclusions We found that heightened cortisol response to mental stress was associated with detectable plasma levels of cTnT using high-sensitivity assays in healthy participants, independently of coronary atherosclerosis. Further research is
needed to understand the role of psychosocial stress in the pathophysiology of cardiac cell damage.|
|Description: ||This paper is in closed access.|
|Publisher Link: ||http://dx.doi.org/10.1016/j.jacc.2013.05.070|
|Appears in Collections:||Closed Access (Sport, Exercise and Health Sciences)|
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