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Title: All-cause mortality effects of replacing sedentary time with physical activity and sleeping using an isotemporal substitution model: a prospective study of 201,129 mid-aged and older adults
Authors: Stamatakis, Emmanuel
Rogers, Kris
Ding, Ding
Berrigan, David
Chau, Josephine Y.
Hamer, Mark
Bauman, Adrian
Keywords: Sedentary behaviour
Mortality
Longitudinal
Isotemporal substitution
Prevention
Sitting
Screen time
Epidemiology
Sleeping
Public health
Population cohort
Physical activity
Issue Date: 2015
Publisher: Biomed Central / © The authors
Citation: STAMATAKIS, E. ... et al, 2015. All-cause mortality effects of replacing sedentary time with physical activity and sleeping using an isotemporal substitution model: a prospective study of 201,129 mid-aged and older adults. International Journal of Behavioral Nutrition and Physical Activity, 12, 121.
Abstract: Background Sedentary behaviour, sleeping, and physical activity are thought to be independently associated with health outcomes but it is unclear whether these associations are due to the direct physiological effects of each behaviour or because, across a finite 24-hour day, engagement in one behavior requires displacement of another. The aim of this study was to examine the replacement effects of sedentary behaviour (total sitting, television/computer screen time combined), sleeping, standing, walking, and moderate-to-vigorous physical activity on all-cause mortality using isotemporal substitution modelling. Methods Longitudinal analysis (4.22 ± 0 · 9 years follow-up/849,369 person-years) of 201,129 participants of the 45 and Up study aged ≥45 years from New South Wales, Australia. Results Seven thousand four hundred and sixty deaths occurred over follow-up. There were beneficial associations for replacing total sitting time with standing (per-hour HR: 95 % CI: 0.95, 0.94–0.96), walking (0.86, 0.81–0.90), moderate-to-vigorous physical activity (0.88, 0.85–0.90), and sleeping in those sleeping ≤ 7 h/day (0.94, 0.90–0.98). Similar associations were noted for replacing screen time. Replacing one hour of walking or moderate-to-vigorous physical activity with any other activity class was associated with an increased mortality risk by 7–18 %. Excluding deaths in the first 24 months of the follow up and restricting analyses to those who were healthy at baseline did not materially change the above observations. Conclusion Although replacing sedentary behaviour with walking and moderate-to-vigorous physical activity are associated with the lowest mortality risk, replacements with equal amounts of standing and sleeping (in low sleepers only) are also linked to substantial mortality risk reductions.
Description: This is an Open Access article published by Biomed Central and distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/)
Sponsor: This research was completed using data collected through the 45 and Up Study (www.saxinstitute.org.au). These analyses were supported by Australian National Health and Medical Research Council Program Grant #301200. This research arises from ES’ personal Career Development Fellowship funded by the National Institute for Health Research (UK).
Version: Published
DOI: 10.1186/s12966-015-0280-7
URI: https://dspace.lboro.ac.uk/2134/19322
Publisher Link: http://dx.doi.org/10.1186/s12966-015-0280-7
ISSN: 1479-5868
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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