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Title: Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-and-mouth disease virus-induced cell lysis
Authors: Giorgakoudi, Kyriaki
Gubbins, Simon
Ward, John P.
Juleff, Nicholas
Zhang, Zhidong
Schley, David
Keywords: Foot-and-mouth disease virus
Cell death
Mathematical model
Partial differential equations
Parameter estimation
Sensitivity analysis
Issue Date: 2015
Publisher: Public Library of Science (PLOS) / © 2015 Giorgakoudi et al.
Citation: GIORGAKOUDI, K. ... et al, 2015. Using mathematical modelling to explore hypotheses about the role of bovine epithelium structure in foot-and-mouth disease virus-induced cell lysis. PLOS ONE, 10(10): e0138571
Abstract: Foot-and-mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals. FMD virus (FMDV) shows a strong tropism for epithelial cells, and FMD is characterised by cell lysis and the development of vesicular lesions in certain epithelial tissues (for example, the tongue). By contrast, other epithelial tissues do not develop lesions, despite being sites of viral replication (for example, the dorsal soft palate). The reasons for this di erence are poorly understood, but hypotheses are di cult to test experimentally. In order to identify the factors which drive cell lysis, and consequently determine the development of lesions, we developed a partial di erential equation model of FMDV infection in bovine epithelial tissues and used it to explore a range of hypotheses about epithelium structure which could be driving di erences in lytic behaviour observed in di erent tissues. Our results demonstrate that, based on current parameter estimates, epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis. However, di erences in receptor distribution or viral replication amongst cell layers could in uence the development of lesions, but only if viral replication rates are much lower than current estimates.
Description: This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Sponsor: This work was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) [grant code: BBS/E/I/00001397].
Version: Published
DOI: 10.1371/journal.pone.0138571
URI: https://dspace.lboro.ac.uk/2134/19384
Publisher Link: http://dx.doi.org/10.1371/journal.pone.0138571
ISSN: 1932-6203
Appears in Collections:Published Articles (Maths)

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