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|Title: ||Modelling foot-and-mouth disease virus dynamics in oral epithelium to help identify the determinants of lysis|
|Authors: ||Schley, David|
Ward, John P.
|Keywords: ||Foot-and-mouth disease virus|
|Issue Date: ||2011|
|Publisher: ||© Springer|
|Citation: ||SCHLEY, D., WARD, J.P. and ZHANG, Z. ... et al, 2011. Modelling foot-and-mouth disease virus dynamics in oral epithelium to help identify the determinants of lysis. Bulletin of Mathematical Biology, 73 (7), pp.1503-1528|
|Abstract: ||Foot-and-mouth disease virus (FMDV) causes an economically important disease of cloven-
hoofed livestock; of interest here is the dfference in lytic behaviour that is observed in bovine epithelium.
On the skin around the feet and tongue the virus rapidly replicates, killing cells and resulting in growing
lesions, before eventually being cleared by the immune response. In contrast there is usually minimal lysis
in the soft palate, but virus may persist in tissue long after the animal has recovered from the disease.
Persistence of virus has important implications for disease control, while identifying the determinant of
lysis in epithelium is potentially important for the development of prophylactics. To help identify which
of the differences between oral and pharyngeal epithelium are responsible for such dramatically divergent
FMDV dynamics a simple model has been developed, in which virus concentration is made explicit to
allow the lytic behaviour of cells to be fully considered. Results suggest that localised structuring of what
are fundamentally similar cells can induce a bifurcation in the behaviour of the system, explicitly whether
infection can be sustained or results mutual extinction, although parameter estimates indicate that more
complex factors may be involved in maintaining viral persistence, or that there are as yet unquantified
differences between the intrinsic properties of cells in these regions.|
|Description: ||The final publication is available at Springer via http://dx.doi.org/10.1007/s11538-010-9576-6|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1007/s11538-010-9576-6|
|Appears in Collections:||Published Articles (Maths)|
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