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Title: Label-free electronic detection of interleukin-6 using horizontally aligned carbon nanotubes
Authors: Chen, Hu
Choo, Teck Kian
Huang, Jingfeng
Wang, Yi
Liu, Yuanjun
Platt, Mark
Palaniappan, Alagappan
Liedberg, Bo
Tok, Alfred I.Y.
Keywords: Interleukin-6
Field-effect transistor
Horizontally aligned single-walled carbon nanotubes
Issue Date: 2015
Publisher: © Elsevier
Citation: CHEN, H. ... et al, 2015. Label-free electronic detection of interleukin-6 using horizontally aligned carbon nanotubes. Materials & Design, 90, pp. 852-857.
Abstract: A facile, sensitive, and label-free assay for detection of interleukin-6 (IL-6) using liquid-gated field-effect transistor (FET) sensors based on horizontally aligned single-walled carbon nanotubes (SWCNT) is proposed. This approach relies on the drain current (Id) responses of the transistor upon interactions of IL-6 with its corresponding antibody (IL-6R) immobilized on SWCNT. The proposed immunosensor exhibits superior sensitivity (limit-of-detection = 1.37 pg/mL) in virtue of the reduced tube-to-tube contact resistance, good selectivity (no responses to bovine serum albumin and cysteine were observed and detection of target molecules in serum was achieved) as a result of the highly specific interaction between IL-6 and IL-6R, and excellent stability (no significant degradation in the electronic performance after storage under ambient conditions for up to 3 months) in virtue of the strong adhesion of CNT to the quartz substrate and good horizontal alignment of these tubes. Therefore, the proposed immunosensor is a promising platform for early diagnosis of various diseases (including some cancers) that can be indicated by the circulating level of IL-6.
Description: This paper is closed access.
Sponsor: This research was funded by the Institute for Sports Research, Nanyang Technological University.
Version: Published
DOI: 10.1016/j.matdes.2015.11.029
URI: https://dspace.lboro.ac.uk/2134/19902
Publisher Link: http://dx.doi.org/10.1016/j.matdes.2015.11.029
ISSN: 0264-1275
Appears in Collections:Closed Access (Chemistry)

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