Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20019

Title: Rapid and non-invasive method to determine toxic levels of alcohols and γ-hydroxylbutyric acid in saliva samples by gas chromatography-differential mobility spectrometry
Authors: Criado-García, L.
Ruszkiewicz, Dorota M.
Eiceman, G.A.
Thomas, C.L. Paul
Keywords: Methanol
Ethanol
Ethylene glycol
1,3-propandiol
Y -hydroxybutyric acid
Saliva
Thermal desorption gas chromatography
Differential mobility spectrometry
Issue Date: 2016
Publisher: © Institute of Physics
Citation: CRIADO-GARCIA, L. ...et al., 2016. Rapid and non-invasive method to determine toxic levels of alcohols and γ-hydroxylbutyric acid in saliva samples by gas chromatography-differential mobility spectrometry. Journal of Breath Research, 10, 017101.
Abstract: A polydimethylsilicone oral sampler was used to extract methanol, ethanol, ethylene glycol, 1,3-propandiol and y-hydroxybutyric acid from samples of human saliva obtained using a passive-drool approach. The extracted compounds were recovered by thermal desorption, isolated by gas chromatography and detected with differential mobility spectrometry, operating with a programmed dispersion field. Complex signal behaviours were also observed that were consistent with hitherto unobserved fragmentation behaviours in differential mobility spectrometry. These yielded high-mobility fragments obscured within the envelope of the water-based reactant ion peak. Further, compensation field maxima shifts were also observed attributable to transport gas modification phenomena. Nevertheless, the responses obtained indicated that in-vivo saliva sampling with thermal desorption gas chromatography may be used to provide a semi-quantitative diagnostic screen over the toxicity threshold concentration ranges of 100 mg.dm-3 to 3 g.dm-3. A candidate method suitable for use in low resource settings for the non-invasive screening of patients intoxicated by alcohols and volatile sedatives has been demonstrated.
Description: This paper is in closed access until 8th Jan 2017.
Version: Accepted for publication
DOI: 10.1088/1752-7155/10/1/017101
URI: https://dspace.lboro.ac.uk/2134/20019
Publisher Link: http://dx.doi.org/10.1088/1752-7155/10/1/017101
ISSN: 1752-7155
Appears in Collections:Closed Access (Chemistry)

Files associated with this item:

File Description SizeFormat
BR-100323 Saliva, alcohols and toxicity text revised 4.02.pdfAccepted version1 MBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.