Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20200

Title: Arm and intensity-matched leg exercise induce similar inflammatory responses
Authors: Leicht, Christof A.
Paulson, Thomas A.W.
Goosey-Tolfrey, Victoria L.
Bishop, Nicolette
Keywords: Chemokines
Sympathetic activation
Upper body exercise
Issue Date: 2016
Publisher: Lippincott, Williams & Wilkins (© American College of Sports Medicine (ACSM))
Citation: LEICHT, C.A. ... et al, 2016. Arm and intensity-matched leg exercise induce similar inflammatory responses. Medicine and Science in Sports and Exercise, 48 (6), pp. 1161-1168.
Abstract: Introduction: The amount of active muscle mass can influence the acute inflammatory response to exercise, associated with reduced risk for chronic disease. This may affect those restricted to upper body exercise, for example due to injury or disability. The purpose of this study was to compare the inflammatory responses for arm exercise and intensity-matched leg exercise. Methods: Twelve male individuals performed three 45-min constant load exercise trials following determination of peak oxygen uptake for arm exercise (V[Combining Dot Above]O2peak A) and cycling (V[Combining Dot Above]O2peak C): (1) arm cranking exercise at 60%V[Combining Dot Above]O2peak A; (2) moderate cycling at 60%V[Combining Dot Above]O2peak C; and (3) easy cycling at 60%V[Combining Dot Above]O2peak A. Cytokine, adrenaline and flow cytometric analysis of monocyte subsets were performed before and up to 4h post exercise. Results: Plasma IL-6 increased from resting concentrations in all trials, however, post exercise concentrations were higher for arm exercise (1.73+/-1.04pg[BULLET OPERATOR]mL-1) and moderate cycling (1.73+/-0.95pg[BULLET OPERATOR]mL-1) compared with easy cycling (0.87+/-0.41pg[BULLET OPERATOR]mL-1,P<0.04). Similarly, the plasma IL-1ra concentration in the recovery period was higher for arm exercise (325+/-139pg[BULLET OPERATOR]mL-1) and moderate cycling (316+/-128pg[BULLET OPERATOR]mL-1) when compared with easy cycling (245+/-77pg[BULLET OPERATOR]mL-1,P<0.04). Arm exercise and moderate cycling induced larger increases in monocyte numbers and larger increases of the classical monocyte subset in the recovery period than easy cycling (P<0.05). The post-exercise adrenaline concentration was lowest for easy cycling (P=0.04). Conclusions: Arm exercise and cycling at the same relative exercise intensity induces a comparable acute inflammatory response; however, cycling at the same absolute oxygen uptake as arm exercise results in a blunted cytokine, monocyte and adrenaline response. Relative exercise intensity appears to be more important to the acute inflammatory response than modality, which is of major relevance for populations restricted to upper body exercise.
Description: This paper is embargoed until June 2017.
Version: Accepted for publication
DOI: 10.1249/MSS.0000000000000874
URI: https://dspace.lboro.ac.uk/2134/20200
Publisher Link: http://dx.doi.org/10.1249/MSS.0000000000000874
ISSN: 0195-9131
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

Files associated with this item:

File Description SizeFormat
MSSE accepted version 13.01.16.pdfAccepted version534.82 kBAdobe PDFView/Open


SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.