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Title: Fabrication of composite poly(ᴅ,ʟ-lactide)/montmorillonite nanoparticles for controlled delivery of acetaminophen by solvent-displacement method using glass capillary microfluidics
Authors: Othman, Rahimah
Vladisavljevic, Goran T.
Thomas, Noreen L.
Nagy, Zoltan K.
Keywords: Montmorillonite
Acetaminophen
Biodegradable nanoparticles
Controlled drug release
Microfludics
Nanoprecipitation
Issue Date: 2016
Publisher: © Elsevier
Citation: OTHMAN, R. ...et al., 2016. Fabrication of composite poly(ᴅ,ʟ-lactide)/montmorillonite nanoparticles for controlled delivery of acetaminophen by solvent-displacement method using glass capillary microfluidics. Colloids and Surfaces B: Biointerfaces, 141, pp.187-195.
Abstract: Paracetamol (PCM)-loaded composite nanoparticles (NPs) composed of a biodegradable poly(ᴅ,ʟ-lactide) (PLA) polymer matrix filled with organically modified montmorillonite (MMT) nanoparticles were fabricated by antisolvent nanoprecipitation in a microfluidic co-flow glass capillary device. The incorporation of MMT in the polymer improved both the drug encapsulation efficiency and the drug loading, and extended the rate of drug release in simulated intestinal fluid (pH 7.4). The particle size increased on increasing both the drug loading and the concentration of MMT in the polymer matrix, and decreased on increasing the aqueous to organic flow rate ratio. The drug encapsulation efficiency in the NPs was higher at higher aqueous to organic flow rate ratio due to faster formation of the NPs. The PCM-loaded PLA NPs containing 2 wt% MMT in PLA prepared at an aqueous to organic flow rate ratio of 10 with an orifice size of 200 μm exhibited a spherical shape with a mean size of 296 nm, a drug encapsulation efficiency of 38.5% and a drug loading of 5.4%. The encapsulation of MMT and PCM in the NPs was confirmed by transmission electron microscopy, energy dispersive x-ray spectroscopy, x-ray diffraction, differential scanning calorimetry, thermogravimetric analysis and attenuated total reflection-Fourier transform infrared spectroscopy.
Description: This paper is in closed access until 27th Jan 2017.
Sponsor: The authors also acknowledge the financial support provided by the EPSRC grant EP/HO29923/1 and the European Research Council grant [280106-CrySys].
Version: Accepted for publication
DOI: 10.1016/j.colsurfb.2016.01.042
URI: https://dspace.lboro.ac.uk/2134/20277
Publisher Link: http://dx.doi.org/10.1016/j.colsurfb.2016.01.042
ISSN: 1873-4367
Appears in Collections:Closed Access (Materials)

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