Loughborough University
Browse
Fabrication of composite poly(d,l-lactide)-montmorillonite nanoparticles for controlled delivery of acetaminophen by solvent-displacement method using glass capillary microfluidics.pdf (548.85 kB)

Fabrication of composite poly(ᴅ,ʟ-lactide)/montmorillonite nanoparticles for controlled delivery of acetaminophen by solvent-displacement method using glass capillary microfluidics

Download (548.85 kB)
journal contribution
posted on 2016-02-09, 14:47 authored by Rahimah Othman, Goran VladisavljevicGoran Vladisavljevic, Noreen Thomas, Zoltan NagyZoltan Nagy
Paracetamol (PCM)-loaded composite nanoparticles (NPs) composed of a biodegradable poly(ᴅ,ʟ-lactide) (PLA) polymer matrix filled with organically modified montmorillonite (MMT) nanoparticles were fabricated by antisolvent nanoprecipitation in a microfluidic co-flow glass capillary device. The incorporation of MMT in the polymer improved both the drug encapsulation efficiency and the drug loading, and extended the rate of drug release in simulated intestinal fluid (pH 7.4). The particle size increased on increasing both the drug loading and the concentration of MMT in the polymer matrix, and decreased on increasing the aqueous to organic flow rate ratio. The drug encapsulation efficiency in the NPs was higher at higher aqueous to organic flow rate ratio due to faster formation of the NPs. The PCM-loaded PLA NPs containing 2 wt% MMT in PLA prepared at an aqueous to organic flow rate ratio of 10 with an orifice size of 200 μm exhibited a spherical shape with a mean size of 296 nm, a drug encapsulation efficiency of 38.5% and a drug loading of 5.4%. The encapsulation of MMT and PCM in the NPs was confirmed by transmission electron microscopy, energy dispersive x-ray spectroscopy, x-ray diffraction, differential scanning calorimetry, thermogravimetric analysis and attenuated total reflection-Fourier transform infrared spectroscopy.

Funding

The authors also acknowledge the financial support provided by the EPSRC grant EP/HO29923/1 and the European Research Council grant [280106-CrySys].

History

School

  • Aeronautical, Automotive, Chemical and Materials Engineering

Department

  • Chemical Engineering

Published in

Colloids and Surfaces B: Biointerfaces

Citation

OTHMAN, R. ...et al., 2016. Fabrication of composite poly(ᴅ,ʟ-lactide)/montmorillonite nanoparticles for controlled delivery of acetaminophen by solvent-displacement method using glass capillary microfluidics. Colloids and Surfaces B: Biointerfaces, 141, pp.187-195.

Publisher

© Elsevier

Version

  • AM (Accepted Manuscript)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/

Publication date

2016

Notes

This paper was accepted for publication in the journal Colloids and Surfaces B: Biointerfaces and the definitive published version is available at http://dx.doi.org/10.1016/j.colsurfb.2016.01.042.

ISSN

1873-4367

Language

  • en