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Title: Recent developments in the design of rapid response cells for laser ablation-inductively coupled plasma-mass spectrometry and their impact on bioimaging applications
Authors: Van Malderen, Stijn J.M.
Managh, Amy J.
Sharp, Barry L.
Vanhaecke, Frank
Issue Date: 2016
Publisher: © Royal Society of Chemistry
Citation: VAN MALDEREN, S.J.M. ...ET AL., 2016. Recent developments in the design of rapid response cells for laser ablation-inductively coupled plasma-mass spectrometry and their impact on bioimaging applications. Journal of Analytical Atomic Spectrometry, 31(2), pp. 423-439.
Abstract: This review covers developments in the design of Laser Ablation (LA) cells, the associated transport tubing assembly,and their coupling to Inductively Coupled Plasma- Mass Spectrometry (ICP-MS) instrumentation. Recent ablation cell designs have reduced the pulse response duration for a single laser shot to <10ms, using the criterion of the full peak width at 1% of the height of the maximum signal intensity. The evolution towards these low dispersion systems has been profoundly influenced by our understanding of processes driving the initial dispersion, of the design aspects of the cell and tubing that influence transport-induced dispersion and transport efficiency, and of limitations imposed by the temporal resolution of ICP-MS instruments, all of which are discussed. Rapid response LA-ICP-MS systems greatly benefit throughput and sensitivity, which are key parameters in 2D and 3D imaging at high lateral resolution. The analysis and imaging of biological material has come to the forefront as a key application of LA- ICP-MS. The impact of the technical developments in LA-ICP-MS systems on emerging applications, including multiplexed metal -tagged antibody detection (for immunohistochemistry), nanoparticle and compound hypo-and hyperaccumulation, and (intra-) cellular /histological studies, is also discussed.
Description: This paper was published as Open Access under a Creative Commons Attribution 3.0 Unported Licence.
Sponsor: Amy Managh acknowledges financial support through a Loughborough University Enterprise Fellowship (Engineering and Physical Sciences Research Council, Impact Acceleration Account.
Version: Published
DOI: 10.1039/C5JA00430F
URI: https://dspace.lboro.ac.uk/2134/20312
Publisher Link: http://dx.doi.org/10.1039/C5JA00430F
ISSN: 0267-9477
Appears in Collections:Published Articles (Chemistry)

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