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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20376

Title: Alginate-lavender nanofibers with antibacterial and antiinflammatory activity to effectively promote burn healing
Authors: Hajiali, Hadi
Summa, Maria
Russo, Debora
Armirotti, Andrea
Brunetti, Virgilio
Bertorelli, Rosalia
Athanassiou, Athanassia
Mele, Elisa
Issue Date: 2016
Publisher: © Royal Society of Chemistry
Citation: HAJIALI, H. ...et al., 2016. Alginate-lavender nanofibers with antibacterial and antiinflammatory activity to effectively promote burn healing. Journal of Materials Chemistry B, 4 (9), pp. 1686-1695.
Abstract: One of the current challenges in wound care is the development of multifunctional dressings that can both protect the wound from external agents and promote the regeneration of the new tissue. Here, we show the combined use of two naturally derived compounds, sodium alginate and lavender essential oil, for the production of bioactive nanofibrous dressings by electrospinning, and their efficacy for the treatment of skin burns induced by midrange ultraviolet radiation (UVB). We demonstrate that the engineered dressings reduce the risk of microbial infection of the burn, since they stop the growth of Staphylococcus aureus. Furthermore, they are able to control and reduce the inflammatory response that is induced in human foreskin fibroblasts by lipopolysaccharides, and in rodents by UVB exposure. In particular, we report a remarkable reduction of pro-inflammatory cytokines when fibroblasts or animals are treated with the alginate-based nanofibers. The down-regulation of cytokines production and the absence of erythema on the skin of the treated animals confirm that the here described dressings are promising as advanced biomedical devices for burn management.
Description: This paper was accepted for publication in the journal Journal of Materials Chemistry B and the definitive published version is available at http://dx.doi.org/10.1039/C5TB02174J
Version: Accepted for publication
DOI: 10.1039/C5TB02174J
URI: https://dspace.lboro.ac.uk/2134/20376
Publisher Link: http://dx.doi.org/10.1039/C5TB02174J
Appears in Collections:Published Articles (Materials)

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