Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Institutional Repository

Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20471

Title: Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential
Authors: Atesok, Kivanc
Fu, Freddie H.
Sekiya, Ichiro
Stolzing, Alexandra
Ochi, Mitsuo
Rodeo, Scott A.
Keywords: Degenerative orthopaedic pathologies
Osteoarthritis
Stem cells
Aging
Tissue regeneration
Issue Date: 2015
Publisher: © European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA). Published by Springer
Citation: ATESOK, K. ...et al., 2015. Stem cells in degenerative orthopaedic pathologies: effects of aging on therapeutic potential. Knee Surgery, Sports Traumatology, Arthroscopy, In Press.
Abstract: © 2015 European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) Purpose: The purpose of this study was to summarize the current evidence on the use of stem cells in the elderly population with degenerative orthopaedic pathologies and to highlight the pathophysiologic mechanisms behind today’s therapeutic challenges in stem cell-based regeneration of destructed tissues in the elderly patients with osteoarthritis (OA), degenerative disc disease (DDD), and tendinopathies.Methods: Clinical and basic science studies that report the use of stem cells in the elderly patients with OA, DDD, and tendinopathies were identified using a PubMed search. The studies published in English have been assessed, and the best and most recent evidence was included in the current study. Results: Evidence suggests that, although short-term results regarding the effects of stem cell therapy in degenerative orthopaedic pathologies can be promising, stem cell therapies do not appear to reverse age-related tissue degeneration. Causes of suboptimal outcomes can be attributed to the decrease in the therapeutic potential of aged stem cell populations and the regenerative capacity of these cells, which might be negatively influenced in an aged microenvironment within the degenerated tissues of elderly patients with OA, DDD, and tendinopathies. Conclusions: Clinical protocols guiding the use of stem cells in the elderly patient population are still under development, and high-level randomized controlled trials with long-term outcomes are lacking. Understanding the consequences of age-related changes in stem cell function and responsiveness of the in vivo microenvironment to stem cells is critical when designing cell-based therapies for elderly patients with degenerative orthopaedic pathologies.
Description: This paper is in closed access.
Version: Published
DOI: 10.1007/s00167-015-3763-9
URI: https://dspace.lboro.ac.uk/2134/20471
Publisher Link: http://dx.doi.org/10.1007/s00167-015-3763-9
ISSN: 0942-2056
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

Files associated with this item:

File Description SizeFormat
aging therapy.pdfPublished version3.69 MBAdobe PDFView/Open

 

SFX Query

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.