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Title: Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems
Authors: Stolzing, Alexandra
Naaldijk, Yahaira
Fedorova, Viktoriya
Sethe, Sebastian
Keywords: Cryopreservation
Hydroxyethyl starch
Stem cells
Issue Date: 2012
Publisher: © Elsevier
Citation: STOLZING, A. ...et al., 2012. Hydroxyethylstarch in cryopreservation - mechanisms, benefits and problems. Transfusion and Apheresis Science, 46(2), pp. 137-147.
Abstract: As the progress of regenerative medicine places ever greater attention on cryopreservation of (stem) cells, tried and tested cryopreservation solutions deserve a second look. This article discusses the use of hydroxyethyl starch (HES) as a cryoprotectant. Charting carefully the recorded uses of HES as a cryoprotectant, in parallel to its further clinical use, indicates that some HES subtypes are a useful supplement to dimethysulfoxide (DMSO) in cryopreservation. However, we suggest that the most common admixture ratio of HES and DMSO in cryoprotectant solutions has been established by historical happenstance and requires further investigation and optimization. © 2012 Elsevier Ltd.
Description: This paper is in closed access.
Version: Published
DOI: 10.1016/j.transci.2012.01.007
URI: https://dspace.lboro.ac.uk/2134/20473
Publisher Link: http://dx.doi.org/10.1016/j.transci.2012.01.007
ISSN: 1473-0502
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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