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Title: Post-menopausal women exhibit greater interleukin-6 responses to mental stress than older men
Authors: Endrighi, Romano
Hamer, Mark
Steptoe, Andrew
Keywords: Sex
Mental stress
Pro-inflammatory reactivity
Interleukin-6
Issue Date: 2016
Publisher: Springer Verlag / © The Authors
Citation: ENDRIGHI, R., HAMER, M. and STEPTOE, A., 2016. Post-menopausal women exhibit greater interleukin-6 responses to mental stress than older men. Annals of Behavioral Medicine, 50 (4), pp.564-571.
Abstract: Background Acute stress triggers innate immune responses and elevation in circulating cytokines including interleukin-6 (IL-6). The effect of sex on IL-6 responses remains unclear due to important limitations of previous studies. Purpose The purpose of this study was to examine sex differences in IL-6 responses to mental stress in a healthy, older (post-menopausal) sample accounting for several moderating factors. Methods Five hundred six participants (62.9 ± 5.60 years, 55 % male) underwent 10 min of mental stress consisting of mirror tracing and Stroop task. Blood was sampled at baseline, after stress, and 45 and 75 min post-stress, and assayed using a high sensitivity kit. IL-6 reactivity was computed as the mean difference between baseline and 45 min and between baseline and 75 min post-stress. Main effects and interactions were examined using ANCOVA models. Results There was a main effect of time for the IL-6 response (F 3,1512 = 201.57, p = <.0001) and a sex by time interaction (F 3,1512 = 17.07, p = <.001). In multivariate adjusted analyses, IL-6 reactivity was significantly greater in females at 45 min (M = 0.37 ± 0.04 vs. 0.20 ± 0.03 pg/mL, p = .01) and at 75 min (M = 0.57 ± 0.05 vs. 0.31 ± 0.05 pg/mL, p = .004) post-stress compared to males. Results were independent of age, adiposity, socioeconomic position, depression, smoking and alcohol consumption, physical activity, statin use, testing time, task appraisals, hormone replacement, and baseline IL-6. Other significant predictors of IL-6 reactivity were lower household wealth, afternoon testing, and baseline IL-6. Conclusions Healthy, post-menopausal females exhibit substantially greater IL-6 responses to acute stress. Inflammatory responses if sustained over time may have clinical implications for the development and maintenance of inflammatory-related conditions prevalent in older women.
Description: This is an Open Access article published by Springer and distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Sponsor: This study was supported by the British Heart Foundation.
Version: Published
DOI: 10.1007/s12160-016-9783-y
URI: https://dspace.lboro.ac.uk/2134/20495
Publisher Link: http://dx.doi.org/10.1007/s12160-016-9783-y
ISSN: 1532-4796
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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