Arthur et al_3-MX_FAIMS_Manuscript_accepted version 2016.pdf (833.93 kB)
Analysis of supramolecular complexes of 3-methylxanthine with field asymmetric waveform ion mobility spectrometry combined with mass spectrometry
journal contribution
posted on 2016-03-15, 11:29 authored by Kayleigh Arthur, Gary Eiceman, Jim ReynoldsJim Reynolds, Colin CreaserMiniaturised field asymmetric waveform ion mobility spectrometry (FAIMS), combined with mass spectrometry (MS), has been applied to the study of self-assembling, non-covalent supramolecular complexes of 3-methylxanthine (3-MX) in the gas phase. 3-MX forms stable tetrameric complexes around an alkali metal (Na+, K+) or ammonium cation, to generate a diverse array of complexes with single and multiple charge states. Complexes of (3-MX)n observed include: singly charged complexes where n = 1-8 and 12 and doubly charged complexes where n = 12-24. The most intense ions are those associated with multiples of tetrameric units, where n = 4, 8, 12, 16, 20, 24. The effect of dispersion field on the ion intensities of the self-assembled complexes indicates some fragmentation of higher order complexes within the FAIMS electrodes (in-FAIMS dissociation), as well as in-source collision induced dissociation within the mass spectrometer. FAIMS-MS enables charge state separation of supramolecular complexes of 3-MX and is shown to be capable of separating species with overlapping mass-to-charge ratios. FAIMS selected transmission also results in an improvement in signal-to-noise ratio for low intensity complexes and enables the visualisation of species undetectable without FAIMS.
History
School
- Science
Department
- Chemistry
Published in
Journal of the American Society for Mass SpectrometryCitation
ARTHUR, K.L. ...et al., 2016. Analysis of supramolecular complexes of 3-methylxanthine with field asymmetric waveform ion mobility spectrometry combined with mass spectrometry. Journal of the American Society for Mass Spectrometry, 27 (5), pp. 800-809.Publisher
© American Society for Mass Spectrometry. Published by Springer Verlag (Germany)Version
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Publication date
2016Notes
The final publication is available at Springer via http://dx.doi.org/10.1007/s13361-016-1351-yISSN
1044-0305Publisher version
Language
- en