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|Title: ||Analysis of supramolecular complexes of 3-methylxanthine with field asymmetric waveform ion mobility spectrometry combined with mass spectrometry|
|Authors: ||Arthur, Kayleigh L.|
Reynolds, James C.
Creaser, Colin S.
|Keywords: ||Field asymmetric waveform ion mobility spectrometry|
Charge state separation
|Issue Date: ||2016|
|Publisher: ||© American Society for Mass Spectrometry. Published by Springer Verlag (Germany)|
|Citation: ||ARTHUR, K.L. ...et al., 2016. Analysis of supramolecular complexes of 3-methylxanthine with field asymmetric waveform ion mobility spectrometry combined with mass spectrometry. Journal of the American Society for Mass Spectrometry, 27 (5), pp. 800-809.|
|Abstract: ||Miniaturised field asymmetric waveform ion mobility spectrometry (FAIMS), combined with mass spectrometry (MS), has been applied to the study of self-assembling, non-covalent supramolecular complexes of 3-methylxanthine (3-MX) in the gas phase. 3-MX forms stable tetrameric complexes around an alkali metal (Na+, K+) or ammonium cation, to generate a diverse array of complexes with single and multiple charge states. Complexes of (3-MX)n observed include: singly charged complexes where n = 1-8 and 12 and doubly charged complexes where n = 12-24. The most intense ions are those associated with multiples of tetrameric units, where n = 4, 8, 12, 16, 20, 24. The effect of dispersion field on the ion intensities of the self-assembled complexes indicates some fragmentation of higher order complexes within the FAIMS electrodes (in-FAIMS dissociation), as well as in-source collision induced dissociation within the mass spectrometer. FAIMS-MS enables charge state separation of supramolecular complexes of 3-MX and is shown to be capable of separating species with overlapping mass-to-charge ratios. FAIMS selected transmission also results in an improvement in signal-to-noise ratio for low intensity complexes and enables the visualisation of species undetectable without FAIMS.|
|Description: ||This paper is in embargoed until February 2017.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1007/s13361-016-1351-y|
|Appears in Collections:||Closed Access (Chemistry)|
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