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Title: Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones.
Authors: De Souza, Mary Jane
Leidy, Heather J.
O'Donnell, Emma
Lasley, Bill
Williams, Nancy I.
Keywords: Humans
Gonadal steroidhormones
Peptide hormones
Case-control studies
Cohort studies
Prospective studies
Life style
Oxygen consumption
Menstrual cycle
Osmolar concentration
Physical education and training
Issue Date: 2004
Publisher: © The Endocrine Society
Citation: DE SOUZA, M.J. ...et al., 2004. Fasting ghrelin levels in physically active women: relationship with menstrual disturbances and metabolic hormones.. The Journal of Clinical Endocrinology and Metabolism, 89(7), pp. 3536-3542.
Abstract: Recent findings support a role for ghrelin in the regulation of energy homeostasis and possibly reproductive function. The primary purpose of this study was to test whether differences in fasting ghrelin levels exist in exercising women with differing menstrual and metabolic status. Menstrual cycle status was defined as sedentary ovulatory (SedOvul; n = 10, cycles = 26), exercising ovulatory (ExOvul; n = 11, cycles = 22), exercising luteal phase defect/anovulatory (ExLPD/Anov; n = 11, cycle = 27), and exercising amenorrheic (ExAmen; n = 8, cycle = 16). Subjects were 27.7 +/- 1.2 yr of age, weighed 60.2 +/- 3.3 kg, and had menstrual cycle lengths of 28.4 +/- 0.9 d. Blood was collected during the follicular phase (d 2-9) of each menstrual cycle and analyzed for total ghrelin, insulin, total T(3), and leptin. Ghrelin was significantly elevated by approximately 85% in the ExAmen category (725.5 +/- 40.8 pmol/liter) when compared with all other categories (P < 0.001; SedOvul = 393.6 +/- 32.0 pmol/liter, ExOvul = 418.9 +/- 34.8 pmol/liter, and ExLPD/Anov = 381.1 +/- 314 pmol/liter). Leptin levels were lower in all groups vs. SedOvul (P < 0.001). Insulin was lower in both the ExLPD/Anov and ExAmen categories vs. SedOvul and ExOvul (P < 0.018), and total T(3) was lower in ExAmen compared with all other groups (P < 0.001), with concentrations in ExLPD/Anov and ExOvul exceeding those in SedOvul (P < 0.05). These data clearly indicate a metabolic hormonal profile consistent with chronic energy deficiency in exercising women across a range in menstrual status and introduces ghrelin as a potential supplementary indicator that uniquely discriminates amenorrheic athletes from athletes with other menstrual disturbances.
Description: This paper is in closed access.
Version: Published
DOI: 10.1210/jc.2003-032007
URI: https://dspace.lboro.ac.uk/2134/20620
Publisher Link: http://dx.doi.org/10.1210/jc.2003-032007
ISSN: 0021-972X
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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