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Title: Alzheimer: nasal transplantation of microglia
Authors: Fabian, Claire
Naaldijk, Yahaira
Stolzing, Alexandra
Keywords: Alzheimer's disease
Mesenchymal stem cells
Issue Date: 2015
Publisher: © Elsevier
Citation: FABIAN, C., NAALDIJK, Y. and STOLZING, A., 2015. Alzheimer: nasal transplantation of microglia. IN: Proceedings of 2014 12th International Symposium on the Neurobiology and Neuroendocrinology of Aging, Bregenz, Austria, 27 July-1 August 2014. Experimental Gerontology, 68, p.93.
Abstract: Alzheimer’s disease (AD) is an age-related neurodegenerative disease associated with the formation of amyloid plaques, [tau] aggregation and oxidative/inflammatory damage. Microglia play an important role in the early phase of the disease and are known to be involved in AD progression. Senescent microglia accumulate in AD causing inflammation, neuronal damage and increasing the A[beta] load. Microglia could be an attractive target for mesenchymal cell therapies (MSC).
Description: This paper was accepted for publication in the journal Experimental Gerontology and the definitive published version is available at http://dx.doi.org/10.1016/j.exger.2015.01.010
Version: Accepted for publication
DOI: 10.1016/j.exger.2015.01.010
URI: https://dspace.lboro.ac.uk/2134/20648
Publisher Link: http://dx.doi.org/10.1016/j.exger.2015.01.010
ISSN: 0531-5565
Appears in Collections:Conference Papers and Presentations (Mechanical, Electrical and Manufacturing Engineering)

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