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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20807

Title: Low-cost and effective fabrication of biocompatible nanofibers from silk and cellulose-rich materials
Authors: Guzman-Puyol, Susana
Heredia-Guerrero, Jose A.
Ceseracciu, Luca
Hajiali, Hadi
Canale, Claudio
Scarpellini, Alice
Cingolani, Roberto
Bayer, Ilker S.
Athanassiou, Athanassia
Mele, Elisa
Keywords: Silk
Issue Date: 2016
Publisher: © American Chemical Society
Citation: GUZMAN-PUYOL, S. ...et al., 2016. Low-cost and effective fabrication of biocompatible nanofibers from silk and cellulose-rich materials. ACS Biomaterials Science & Engineering, In Press.
Abstract: Here, we show the production of nanofibrous mats with controlled mechanical properties and excellent biocompatibility by combining fibroin with pure cellulose and cellulose-rich parsley powder agro-waste. To this end, trifluoroacetic acid was used as a common solvent for all of the involved biomaterials, achieving highly homogeneous blends that were suitable for the electrospinning technique. Morphological analysis revealed that the electrospun composite nanofibers were well-defined and defect-free, with a diameter in the range of 65−100 nm. Mechanical investigations demonstrated that the fibrous mats exhibited an increased stiffness when pure fibroin was combined with cellulose, whereas they possessed an increased flexibility when the parsley waste was added to fibroin. Lastly, the produced mats were highly biocompatible, as demonstrated by the promoted proliferation of fibroblast cells. The characteristics of the hybrid fibroin−cellulose nanofibers, in terms of nanoscale topography, mechanical properties, and biocompatibility, are attractive and potentially applicable in the biomedical sector.
Description: This paper is in closed access.
Version: Accepted for publication
DOI: 10.1021/acsbiomaterials.5b00500
URI: https://dspace.lboro.ac.uk/2134/20807
Publisher Link: http://dx.doi.org/10.1021/acsbiomaterials.5b00500
ISSN: 2373-9878
Appears in Collections:Closed Access (Materials)

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