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|Title: ||The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study|
|Authors: ||Dungey, Maurice|
Young, Hannah M.L.
Burton, James O.
Smith, Alice C.
|Keywords: ||Blood pressure|
|Issue Date: ||2015|
|Publisher: ||© The Author(s) Published by S. Karger AG, Basel|
|Citation: ||DUNGEY, M. ... et al., 2015. The impact of exercising during haemodialysis on blood pressure, markers of cardiac injury and systemic inflammation - preliminary results of a pilot study. Kidney and Blood Pressure Research, 40 (6), pp. 593 - 604.|
|Abstract: ||Background/Aims: Patients requiring haemodialysis have cardiovascular and immune
dysfunction. Little is known about the acute effects of exercise during haemodialysis. Exercise
has numerous health benefits but in other populations has a profound impact upon blood
pressure, inflammation and immune function; therefore having the potential to exacerbate
cardiovascular and immune dysfunction in this vulnerable population. Methods: Fifteen
patients took part in a randomised-crossover study investigating the effect of a 30-min
bout of exercise during haemodialysis compared to resting haemodialysis. We assessed
blood pressure, plasma markers of cardiac injury and systemic inflammation and neutrophil
degranulation. Results: Exercise increased blood pressure immediately post-exercise; however,
1 hour after exercise blood pressure was lower than resting levels (106±22 vs. 117±25 mm
Hg). No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms.
Exercise did not alter circulating concentrations of IL-6, TNF-α or IL-1ra nor clearly suppress
neutrophil function. Conclusions: This study demonstrates fluctuations in blood pressure
during haemodialysis in response to exercise. However, since the fall in blood pressure
occurred without evidence of cardiac injury, we regard it as a normal response to exercise
superimposed onto the haemodynamic response to haemodialysis. Importantly, exercise did
not exacerbate systemic inflammation or immune dysfunction; intradialytic exercise was well
|Description: ||This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
License (CC BY-NC-ND) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution
for commercial purposes as well as any distribution of modified material requires written permission.|
|Sponsor: ||This work was supported by the National Institute for Health Research (NIHR) Diet,
Lifestyle & Physical Activity Biomedical Research Unit based at University Hospitals of
Leicester and Loughborough University.|
|Publisher Link: ||http://dx.doi.org/10.1159/000368535|
|Appears in Collections:||Published Articles (Sport, Exercise and Health Sciences)|
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