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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/20920

Title: A review on electronic bio-sensing approaches based on non-antibody recognition elements
Authors: Chen, Hu
Huang, Jingfeng
Palaniappan, Alagappan
Wang, Yi
Liedberg, Bo
Platt, Mark
Tok, Alfred I.Y.
Keywords: Antibodies
Issue Date: 2016
Publisher: © RSC
Citation: CHEN, H. ... et al., 2016. A review on electronic bio-sensing approaches based on non-antibody recognition elements. Analyst, 141, pp.2335-2346.
Abstract: In this review, recent advances in the development of electronic detection methodologies based on non-antibody recognition elements such as functional liposomes, aptamers and synthetic peptides are discussed. Particularly, we highlight the progress of field effect transistor (FET) sensing platforms where possible as the number of publications on FET-based platforms has increased rapidly. Biosensors involving antibody-antigen interactions have been widely applied in diagnostics and healthcare in virtue of their superior selectivity and sensitivity, which can be attributed to their high binding affinity and extraordinary specificity, respectively. However, antibodies typically suffer from fragile and complicated functional structures, large molecular size and sophisticated preparation approaches (resource-intensive and time-consuming), resulting in limitations such as short shelf-life, insufficient stability and poor reproducibility. Recently, bio-sensing approaches based on synthetic elements have been intensively explored. In contrast to existing reports, this review provides a comprehensive overview of recent advances in the development of biosensors utilizing synthetic recognition elements and a detailed comparison of their assay performances. Therefore, this review would serve as a good summary of the efforts for the development of electronic bio-sensing approaches involving synthetic recognition elements.
Description: This paper was accepted for publication in the journal Analyst and the definitive published version is available at http://dx.doi.org/10.1039/C5AN02623G.
Sponsor: This research was funded by the Institute for Sports Research, Nanyang Technological University and Loughborough University.
Version: Accepted for publication
DOI: 10.1039/C5AN02623G
URI: https://dspace.lboro.ac.uk/2134/20920
Publisher Link: http://dx.doi.org/10.1039/C5AN02623G
ISSN: 0003-2654
Appears in Collections:Published Articles (Chemistry)

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