BUCKLEY, B. ... et al., 2016. A new simplified protocol for copper(I) alkyne–azide cycloaddition reactions using low substoichiometric amounts of copper(II) precatalysts in methanol. SYNLETT, DOI: 10.1055/s-0035-1560526.
Copper(II) carboxylates are reduced efficiently by methanol in the presence of alkynes and form yellow alkynylcopper(I) polymeric precatalysts that are involved with azides, in the absence of added ligands, in the catalytic cycles that result in the formation of 1,4-disubstituted 1,2,3-triazoles.
This item will remain closed access until 12/11/2016.
The authors are grateful to The Higher Education Commission of Pakistan for a visiting fellowship (to A.N.K.) and the EU Lifelong Learning Programme for support (to M.M.P.F), and Loughborough University for research funding. B.R.B. also thanks Research Councils UK for a RCUK fellowship.