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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/21619

Title: Production of fluconazole-loaded polymeric micelles using membrane and microfluidic dispersion devices
Authors: Lu, Yu
Chowdhury, Danial
Vladisavljevic, Goran T.
Koutroumanis, Konstantinos P.
Georgiadou, Stella
Keywords: Polymeric micelles
Microfluidic co-flow
Membrane contactor
Drug-loaded micelles
Diblock copolymers
Issue Date: 2016
Publisher: MDPI (© the authors)
Citation: LU, Y. ... et al., 2016. Production of fluconazole-loaded polymeric micelles using membrane and microfluidic dispersion devices. Membranes, 6 (2), pp.1-19.
Abstract: Polymeric micelles with a controlled size in the range between 41 and 80 nm were prepared by injecting the organic phase through a microengineered nickel membrane or a tapered-end glass capillary into an aqueous phase. The organic phase was composed of 1 mg mL 1 of PEG-b-PCL diblock copolymers with variable molecular weights, dissolved in tetrahydrofuran (THF) or acetone. The pore size of the membrane was 20 m and the aqueous/organic phase volumetric flow rate ratio ranged from 1.5 to 10. Block copolymers were successfully synthesized withMn ranging from ~9700 to 16,000 g mol 1 and polymeric micelles were successfully produced from both devices. Micelles produced from the membrane device were smaller than those produced from the microfluidic device, due to the much smaller pore size compared with the orifice size in a co-flow device. The micelles were found to be relatively stable in terms of their size with an initial decrease in size attributed to evaporation of residual solvent rather than their structural disintegration. Fluconazole was loaded into the cores of micelles by injecting the organic phase composed of 0.5–2.5 mg mL 1 fluconazole and 1.5 mg mL 1 copolymer. The size of the drug-loaded micelles was found to be significantly larger than the size of empty micelles.
Sponsor: This project was completed with the support of the Engineering and Physical Sciences Research Council of the United Kingdom (the grant reference number: EP/HO29923/1).
Version: Published
DOI: 10.3390/membranes6020029
URI: https://dspace.lboro.ac.uk/2134/21619
Publisher Link: http://dx.doi.org/10.3390/membranes6020029
ISSN: 2077-0375
Appears in Collections:Published Articles (Chemical Engineering)

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