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Title: Biomarkers to identify and isolate senescent cells.
Authors: Matjusaitis, Mantas
Chin, Greg
Sarnoski, Ethan Anders
Stolzing, Alexandra
Keywords: Senescence
Cell biology
Issue Date: 2016
Publisher: © Elsevier
Citation: MATJUSAITIS, M. ...et al., 2016. Biomarkers to identify and isolate senescent cells. Ageing Research Reviews, 29, pp. 1-12.
Abstract: Aging is the main risk factor for many degenerative diseases and declining health. Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction. These cells can negatively affect neighbouring cells through an altered secretory phenotype: the senescence-associated secretory phenotype (SASP). The SASP induces senescence in healthy cells, promotes tumour formation and progression, and contributes to other age-related diseases such as atherosclerosis, immune-senescence and neurodegeneration. Removal of senescent cells was recently demonstrated to delay age-related degeneration and extend lifespan. To better understand cell aging and to reap the benefits of senescent cell removal, it is necessary to have a reliable biomarker to identify these cells. Following an introduction to cellular senescence, we discuss several classes of biomarkers in the context of their utility in identifying and/or removing senescent cells from tissues. Although senescence can be induced by a variety of stimuli, senescent cells share some characteristics that enable their identification both in vitro and in vivo. Nevertheless, it may prove difficult to identify a single biomarker capable of distinguishing senescence in all cell types. Therefore, this will not be a comprehensive review of all senescence biomarkers but rather an outlook on technologies and markers that are most suitable to identify and isolate senescent cells.
Description: This paper was accepted for publication in the journal Ageing Research Reviews and the definitive published version is available at http://dx.doi.org/10.1016/j.arr.2016.05.003.
Sponsor: The work presented in this paper was made possible by funding from the German Federal Ministry of Education and Research (BMBF1315883)
Version: Accepted for publication
DOI: 10.1016/j.arr.2016.05.003
URI: https://dspace.lboro.ac.uk/2134/21676
Publisher Link: http://dx.doi.org/10.1016/j.arr.2016.05.003
ISSN: 1568-1637
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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