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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/21737

Title: Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel
Authors: Schiavone, Alessandro
Abunassar, C.
Hossainy, S.
Zhao, Liguo
Keywords: Bioresorbable scaffold
Stent crimping
Stent deployment
Eccentric plaque
Issue Date: 2016
Publisher: © Elsevier
Citation: SCHIAVONE, A. ...et al., 2016. Computational analysis of mechanical stress-strain interaction of a bioresorbable scaffold with blood vessel. Journal of Biomechanics, 49 (13), pp. 2677-2683.
Abstract: Crimping and deployment of bioresorbable polymeric scaffold, Absorb, were modelled using finite element method, in direct comparison with Co-Cr alloy drug eluting stent, Xience V. Absorb scaffold has an expansion rate lower than Xience V stent, with a less outer diameter achieved after balloon deflation. Due to the difference in design and material properties, Absorb also shows a higher recoiling than Xience V, which suggests that additional post-dilatation is required to achieve effective treatment for patients with calcified plaques and stiff vessels. However, Absorb scaffold induces significantly lower stresses on the artery-plaque system, which can be clinically beneficial. Eccentric plaque causes complications to stent deployment, especially non-uniform vessel expansion. Also the stress levels in the media and adventitia layers are considerably higher for the plaque with high eccentricity, for which the choice of stents, in terms of materials and designs, will be of paramount importance. Our results imply that the benefits of Absorb scaffolds are amplified in these cases.
Description: This paper was accepted for publication in the journal Journal of Biomechanics and the definitive published version is available at http://dx.doi.org/10.1016/j.jbiomech.2016.05.035
Version: Accepted for publication
DOI: 10.1016/j.jbiomech.2016.05.035
URI: https://dspace.lboro.ac.uk/2134/21737
Publisher Link: http://dx.doi.org/10.1016/j.jbiomech.2016.05.035
ISSN: 1873-2380
Appears in Collections:Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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