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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/21837

Title: Using SITAR to relate pubertal growth to bone health in later life: the MRC National Survey of Health and Development
Authors: Cole, Tim J.
Kuh, D.
Johnson, William O.
Ward, K.A.
Howe, Laura D.
Adams, Judith E.
Hardy, Roger
Ong, K.K.
Keywords: SITAR
Bone density
Issue Date: 2016
Publisher: © Oxford University Press
Citation: COLE, T.J. ... et al, 2016. Using SITAR to relate pubertal growth to bone health in later life: the MRC National Survey of Health and Development. International Journal of Epidemiology, forthcoming.
Abstract: Background: To explore associations between pubertal growth and later bone health in a cohort with infrequent measurements, using another cohort with more frequent measurements to support the modelling, data from the MRC National Survey of Health and Development (2-26 years, 4901/30 004 subjects/measurements) and the Avon Longitudinal Study of Parents and Children (5-20 years) (10 896/74 120) were related to NSHD bone health outcomes at 60-64 years. Methods: NSHD data were analysed using SITAR growth curve analysis, either alone or jointly with ALSPAC data. Improved estimation of pubertal growth parameters of size, tempo and velocity was assessed by changes in model fit and correlations with contemporary measures of pubertal timing. Bone outcomes of radius (trabecular volumetric bone mineral density (vBMD) and diaphysis cross-sectional area (CSA)) were regressed on the SITAR parameters, adjusted for current body size. Results: The NSHD SITAR parameters were better estimated in conjunction with ALSPAC, i.e. more strongly correlated with pubertal timing. Trabecular vBMD was associated with early height tempo, while diaphysis CSA was related to weight size, early tempo and slow velocity, the bone outcomes being around 15% higher for the better versus worse growth pattern. Conclusions: By pooling NSHD and ALSPAC data, SITAR more accurately summarised pubertal growth and weight gain in NSHD, and in turn demonstrated notable associations between pubertal timing and later bone outcomes. These associations give insight into the importance of the pubertal period for future skeletal health and osteoporosis risk.
Description: This paper is embargoed until 12 months after online publication.
Sponsor: The research was supported by the National Institute for Health Research Biomedical Research Centre at Great Ormond Street Hospital for Children NHS Foundation Trust and University College London.
Version: Accepted for publication
URI: https://dspace.lboro.ac.uk/2134/21837
Publisher Link: http://ije.oxfordjournals.org/
ISSN: 1464-3685
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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