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Title: EPA/DHA dietary supplementation attenuates exercise-induced bronchoconstriction in physically active asthmatic males
Authors: Kumar, Aishwarya
Mastana, Sarabjit S.
Lindley, Martin R.
Issue Date: 2016
Publisher: © The Authors. Published by Taylor & Francis
Citation: KUMAR, A., MASTANA, S.S. and LINDLEY, M.R., 2016. EPA/DHA dietary supplementation attenuates exercise-induced bronchoconstriction in physically active asthmatic males. Cogent Medicine, 3:1172696
Abstract: Asthma is a common and prevalent health problem, globally affecting over 300 million individuals. Observational and intervention studies have shown beneficial effects of omega-3 [Eicosapentaenoic Acid (EPA) and Docosahexaenoic acid (DHA)] on asthma and exercise-induced bronchoconstriction (EIB). Due to health side effects with pharmacological medication, use of complementary therapies including omega-3 supplementation is gaining impetus. A double-blinded randomised crossover pilot study with 3 weeks of supplementation (3.2 g EPA and 2.2 g DHA or placebo) was conducted to assess the effect of omega-3 supplementation in physically active males with EIB (n = 9, 21 ± 0.9 years, Forced Expiratory Volume in 1-s/Forced Vital Capacity (FEV1/FVC) = 77 ± 1.4). At the start of study, participants showed abnormal lung function, typical drop of >10% in their FEV1 following exercise-challenge tests; elevated levels of Exhaled-breath Nitric oxide, FeNO (>40 ppb). The 3-week supplementation resulted in a significant improvement in post-exercise pulmonary function (PF) (<10% drop in post-exercise FEV1/FVC), supported by significant reduction in serum IL-6 levels (37% reduction). Although no significant changes were observed for Peripheral Blood Mononuclear Cell (PBMC) total lipid composition for EPA/DHA, non-significant increase in total PBMC EPA/DHA with reduction in omega-6 fatty acid (Arachidonic Acid) was observed. This pilot study shows a beneficial effect of 3 weeks of omega-3 supplementation on PF for EIB-participants.
Description: This is an Open Access Article. It is published by Taylor and Francis under the Creative Commons Attribution 4.0 Unported Licence (CC BY). Full details of this licence are available at: http://creativecommons.org/licenses/by/4.0/
Version: Published
DOI: 10.1080/2331205X.2016.1172696
URI: https://dspace.lboro.ac.uk/2134/21879
Publisher Link: http://dx.doi.org/10.1080/2331205X.2016.1172696
ISSN: 2331-205X
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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