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Genetics of coronary heart.pdf (880.28 kB)

Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region.

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journal contribution
posted on 2016-07-01, 10:47 authored by Suraksha Agrawal, Sarabjit MastanaSarabjit Mastana
Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease (CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. Molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific "candidate genes", which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CIII-AIV gene clusters have been discussed.

History

School

  • Sport, Exercise and Health Sciences

Published in

World journal of cardiology

Volume

6

Issue

8

Pages

755 - 763

Citation

AGRAWAL, S. and MASTANA, S.S., 2014. Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region.. World Journal of Cardiology, 6(8), pp. 755-763.

Publisher

© The Authors. Published by Baishideng Publishing Group Inc

Version

  • VoR (Version of Record)

Publisher statement

This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) licence. Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

Publication date

2014

Notes

This is an Open Access Article. It is published by Baishideng Publishing Group under the Creative Commons Attribution 4.0 Unported Licence (CC BY-NC). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/

eISSN

1949-8462

Language

  • en