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Title: Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region.
Authors: Agrawal, Suraksha
Mastana, Sarabjit S.
Keywords: ApoAI-CIII-AIV gene cluster
Haplotype analysis
Single nucleotide polymorphism
Candidate gene study
Genome wide association studies
Issue Date: 2014
Publisher: © The Authors. Published by Baishideng Publishing Group Inc
Citation: AGRAWAL, S. and MASTANA, S.S., 2014. Genetics of coronary heart disease with reference to ApoAI-CIII-AIV gene region.. World Journal of Cardiology, 6(8), pp. 755-763.
Abstract: Cardiovascular diseases are affected by multiple factors like genetic as well as environmental hence they reveal factorial nature. The evidences that genetic factors are susceptible for developing cardiovascular diseases come from twin studies and familial aggregation. Different ethnic populations reveal differences in the prevalence coronary artery disease (CAD) pointing towards the genetic susceptibility. With progression in molecular techniques different developments have been made to comprehend the disease physiology. Molecular markers have also assisted to recognize genes that may provide evidences to evaluate the role of genetic factors in causation of susceptibility towards CAD. Numerous studies suggest the contribution of specific "candidate genes", which correlate with various roles/pathways that are involved in the coronary heart disease. Different studies have revealed that there are large numbers of genes which are involved towards the predisposition of CAD. However, these reports are not consistent. One of the reasons could be weak contribution of genetic susceptibility of these genes. Genome wide associations show different chromosomal locations which dock, earlier unknown, genes which may attribute to CAD. In the present review different ApoAI-CIII-AIV gene clusters have been discussed.
Description: This is an Open Access Article. It is published by Baishideng Publishing Group under the Creative Commons Attribution 4.0 Unported Licence (CC BY-NC). Full details of this licence are available at: http://creativecommons.org/licenses/by-nc/4.0/
Version: Published
DOI: 10.4330/WJC.v6.i8.755
URI: https://dspace.lboro.ac.uk/2134/21883
Publisher Link: http://dx.doi.org/10.4330/WJC.v6.i8.755
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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