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Title: Unity in diversity: An overview of the genomic anthropology of India
Authors: Mastana, Sarabjit S.
Keywords: Alu
Genomic variation
Issue Date: 2014
Publisher: © Taylor & Francis
Citation: MASTANA, S.S., 2014. Unity in diversity: An overview of the genomic anthropology of India. Annals of Human Biology, 41(4), pp. 287-299.
Abstract: Context: India is considered a treasure for geneticists and evolutionary biologists due to its vast human diversity, consisting of more than 4500 anthropologically well-defined populations (castes, tribes and religious groups). Each population differs in terms of endogamy, language, culture, physical features, geographic and climatic position and genetic architecture. These factors contributed to India-specific genetic variations which may be responsible for various common diseases in India and its migratory populations. As a result, interpretations of the origins and affinities of Indian populations as well as health and disease conditions require complex and sophisticated genetic analysis. Evidence of ancient human dispersals and settlements is preserved in the genome of Indian inhabitants and this has been extensively analysed in conventional and genomic analyses. Objective and methods: Using genomic analyses of STRs and Alu on a set of populations, this study estimates the level and extent of genetic variation and its implications. Results: The results show that Indian populations have a higher level of unique genetic diversity which is structured by many social processes and geographical attributes of the country. Conclusion: This overview highlights the need to study the anthropological structure and evolutionary history of Indian populations while designing genomic and epigenomic investigations. © 2014 Informa UK Ltd.
Description: This is an Accepted Manuscript of an article published by Taylor & Francis in Annals of Human Biology on 16th Jun 2014, available online: http://dx.doi.org/10.3109/03014460.2014.922615
Version: Accepted for publication
DOI: 10.3109/03014460.2014.922615
URI: https://dspace.lboro.ac.uk/2134/21885
Publisher Link: http://dx.doi.org/10.3109/03014460.2014.922615
ISSN: 0301-4460
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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