Abou-El-Nein_20160429_Manuscript_Final.pdf (478 kB)
Putting a price tag on novel autologous cellular therapies
journal contribution
posted on 2016-07-07, 08:21 authored by Mohamed Abou-El-Enein, Gerhard Bauer, Nick Medcalf, Hans-Dieter Volk, Petra ReinkeCell therapies, especially autologous therapies, pose significant challenges to researchers who wish to move from small, probably academic, methods of manufacture to full commercial scale. There is a dearth of reliable information about the costs of operation, and this makes it difficult to predict with confidence the investment needed to translate the innovations to the clinic, other than as small-scale, clinician-led prescriptions. Here, we provide an example of the results of a cost model that takes into account the fixed and variable costs of manufacture of one such therapy. We also highlight the different factors that influence the product final pricing strategy. Our findings illustrate the need for cooperative and collective action by the research community in pre-competitive research to generate the operational models that are much needed to increase confidence in process development for these advanced products.
Funding
This work was partially supported by a DFG-grant: SFB-TR36, project A2
History
School
- Mechanical, Electrical and Manufacturing Engineering
Published in
CytotherapyCitation
ABOU-EL-ENEIN, M. ... et al., 2016. Putting a price tag on novel autologous cellular therapies. Cytotherapy, 18 (8), pp. 1056–1061.Publisher
© International Society for Cellular Therapy. Published by Elsevier Inc.Version
- AM (Accepted Manuscript)
Publisher statement
This work is made available according to the conditions of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) licence. Full details of this licence are available at: https://creativecommons.org/licenses/by-nc-nd/4.0/Acceptance date
2016-05-09Publication date
2016Notes
This paper was accepted for publication in the journal Cytotherapy and the definitive published version is available at http://dx.doi.org/10.1016/j.jcyt.2016.05.005ISSN
1465-3249eISSN
1477-2566Publisher version
Language
- en