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|Title: ||Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer|
|Authors: ||Heaney, Liam M.|
Ruszkiewicz, Dorota M.
Arthur, Kayleigh L.
Lindley, Martin R.
Thomas, C.L. Paul
Turner, Matthew A.
Reynolds, James C.
|Issue Date: ||2016|
|Publisher: ||© Future Science Ltd|
|Citation: ||HEANEY, L.M. ...et al., 2016. Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer. Bioanalysis, 8(13), pp. 1325-1336.|
|Abstract: ||© 2016 Future Science Ltd.Aim: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. Conclusion: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.|
|Description: ||This paper was accepted for publication in the journal Bioanalysis and the definitive published version is available at http://dx.doi.org/10.4155/bio-2016-0045.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.4155/bio-2016-0045|
|Appears in Collections:||Published Articles (Chemistry)|
Published Articles (Sport, Exercise and Health Sciences)
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