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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/22012

Title: Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer
Authors: Heaney, Liam M.
Ruszkiewicz, Dorota M.
Arthur, Kayleigh L.
Hadjithekli, Andria
Aldcroft, Clive
Lindley, Martin R.
Thomas, C.L. Paul
Turner, Matthew A.
Reynolds, James C.
Issue Date: 2016
Publisher: © Future Science Ltd
Citation: HEANEY, L.M. ...et al., 2016. Real-time monitoring of exhaled volatiles using atmospheric pressure chemical ionization on a compact mass spectrometer. Bioanalysis, 8(13), pp. 1325-1336.
Abstract: © 2016 Future Science Ltd.Aim: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. Conclusion: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
Description: This paper is in closed access until July 2017.
Version: Accepted for publication
DOI: 10.4155/bio-2016-0045
URI: https://dspace.lboro.ac.uk/2134/22012
Publisher Link: http://dx.doi.org/10.4155/bio-2016-0045
ISSN: 1757-6180
Appears in Collections:Closed Access (Sport, Exercise and Health Sciences)

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