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Title: Graphic patterns of cortical functional connectivity of depressed patients on the basis of EEG measurements
Authors: Sun, Yu
Hu, Sijung
Chambers, Jonathon
Zhu, Yisheng
Tong, Shanbao
Keywords: Depression
Partial directed coherence
Small-world network
Issue Date: 2011
Publisher: © IEEE
Citation: SUN, Y. ... et al., 2011. Graphic patterns of cortical functional connectivity of depressed patients on the basis of EEG measurements. IN: Proceedings of 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEMBS 2011), Boston, United States, 30 August-3 September 2011, pp.1419-1422.
Abstract: Considerable evidences have shown a decrease of neu-ronal activity in the left frontal lobe of depressed patients, but the underlying cortical network is still unclear. The present study intends to investigate the conscious-state brain network patterns in depressed patients compared with control individuals. Cortical functional connectivity is quantified by the partial directed coherence (PDC) analysis of multichannel EEG signals from 12 depressed patients and 12 healthy volunteers. The corresponding PDC matrices are first converted into unweighted graphs by applying a threshold to obtain the topographic property in-degree (K in). A significantly larger K in in the left hemisphere is identified in depressed patients, while a symmetric pattern is found in the control group. Another two topographic measures, i.e., clustering coefficients (C) and characteristic path length (L), are obtained from the original weighted PDC digraphs. Compared with control individuals, significantly smaller C and L are revealed in the depression group, indicating a random network-like architecture due to affective disorder. This study thereby provides further support for the presence of a hemispheric asymmetry syndrome in the depressed patients. More importantly, we present evidence that depression is characterized by a loss of optimal small-world network characteristics in conscious state.
Description: Closed access.
Version: Published
DOI: 10.1109/IEMBS.2011.6090334
URI: https://dspace.lboro.ac.uk/2134/22178
Publisher Link: http://dx.doi.org/10.1109/IEMBS.2011.6090334
ISBN: 9781424441211
ISSN: 1557-170X
Appears in Collections:Closed Access (Mechanical, Electrical and Manufacturing Engineering)

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