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|Title: ||Customisable 3D printed microfluidics for integrated analysis and optimisation|
|Authors: ||Monaghan, Thomas|
Harris, Russell A.
Friel, Ross J.
Christie, Steven D.R.
|Issue Date: ||2016|
|Publisher: ||© Royal Society of Chemistry|
|Citation: ||MONAGHAN, T. ...et al., 2016. Customisable 3D printed microfluidics for integrated analysis and optimisation. Lab On a Chip, 16 (17), pp. 3362-3373.|
|Abstract: ||The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered
by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC
devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic
performance of a variety of optical fibre combinations were tested, and the optimum path length for
performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was
then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high
resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range
of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation.
This ability to tailor the chip design and its integrated features as a direct result of the reaction being
assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device
and reaction. As a result of the information gained in this investigation, we are able to report the first
instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded
optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.|
|Description: ||This paper was accepted for publication in the journal Lab On a Chip and the definitive published version is available at http://dx.doi.org/10.1039/C6LC00562D.|
|Sponsor: ||This work was supported by the Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1039/C6LC00562D|
|Appears in Collections:||Published Articles (Chemistry)|
Published Articles (Mechanical, Electrical and Manufacturing Engineering)
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