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Please use this identifier to cite or link to this item: https://dspace.lboro.ac.uk/2134/22219

Title: Customisable 3D printed microfluidics for integrated analysis and optimisation
Authors: Monaghan, Thomas
Harding, Matthew J.
Harris, Russell A.
Friel, Ross J.
Christie, Steven D.R.
Issue Date: 2016
Publisher: © Royal Society of Chemistry
Citation: MONAGHAN, T. ...et al., 2016. Customisable 3D printed microfluidics for integrated analysis and optimisation. Lab On a Chip, 16 (17), pp. 3362-3373.
Abstract: The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic performance of a variety of optical fibre combinations were tested, and the optimum path length for performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation. This ability to tailor the chip design and its integrated features as a direct result of the reaction being assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device and reaction. As a result of the information gained in this investigation, we are able to report the first instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded optical fibres capable of performing UV-vis spectroscopy directly inside micro channels.
Description: This paper was accepted for publication in the journal Lab On a Chip and the definitive published version is available at http://dx.doi.org/10.1039/C6LC00562D.
Sponsor: This work was supported by the Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing.
Version: Accepted for publication
DOI: 10.1039/C6LC00562D
URI: https://dspace.lboro.ac.uk/2134/22219
Publisher Link: http://dx.doi.org/10.1039/C6LC00562D
ISSN: 1473-0197
Appears in Collections:Published Articles (Chemistry)
Published Articles (Mechanical, Electrical and Manufacturing Engineering)

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