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Title: | Customisable 3D printed microfluidics for integrated analysis and optimisation |
Authors: | Monaghan, Thomas Harding, Matthew Harris, Russell A. Friel, Ross J. Christie, Steven D.R. |
Issue Date: | 2016 |
Publisher: | © Royal Society of Chemistry |
Citation: | MONAGHAN, T. ...et al., 2016. Customisable 3D printed microfluidics for integrated analysis and optimisation. Lab On a Chip, 16 (17), pp. 3362-3373. |
Abstract: | The formation of smart Lab-on-a-Chip (LOC) devices featuring integrated sensing optics is currently hindered
by convoluted and expensive manufacturing procedures. In this work, a series of 3D-printed LOC
devices were designed and manufactured via stereolithography (SL) in a matter of hours. The spectroscopic
performance of a variety of optical fibre combinations were tested, and the optimum path length for
performing Ultraviolet-visible (UV-vis) spectroscopy determined. The information gained in these trials was
then used in a reaction optimisation for the formation of carvone semicarbazone. The production of high
resolution surface channels (100–500 μm) means that these devices were capable of handling a wide range
of concentrations (9 μM–38 mM), and are ideally suited to both analyte detection and process optimisation.
This ability to tailor the chip design and its integrated features as a direct result of the reaction being
assessed, at such a low time and cost penalty greatly increases the user's ability to optimise both their device
and reaction. As a result of the information gained in this investigation, we are able to report the first
instance of a 3D-printed LOC device with fully integrated, in-line monitoring capabilities via the use of embedded
optical fibres capable of performing UV-vis spectroscopy directly inside micro channels. |
Description: | This paper was accepted for publication in the journal Lab On a Chip and the definitive published version is available at http://dx.doi.org/10.1039/C6LC00562D. |
Sponsor: | This work was supported by the Engineering and Physical Science Research Council (EPSRC) via the Centre for Innovative Manufacturing in Additive Manufacturing. |
Version: | Accepted for publication |
DOI: | 10.1039/C6LC00562D |
URI: | https://dspace.lboro.ac.uk/2134/22219 |
Publisher Link: | http://dx.doi.org/10.1039/C6LC00562D |
ISSN: | 1473-0197 |
Appears in Collections: | Published Articles (Chemistry) Published Articles (Mechanical, Electrical and Manufacturing Engineering)
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