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Title: Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity
Authors: Svendsen, Ida S.
Hem, Erlend
Gleeson, Michael
Keywords: Altitude
Endurance
Cortisol
S-IgA
Cytokine
Lymphocytes
Issue Date: 2016
Publisher: Springer Verlag © The Author(s)
Citation: SVENDSEN, I.S., HEM, E. and GLEESON, M., 2016. Effect of acute exercise and hypoxia on markers of systemic and mucosal immunity. European Journal of Applied Physiology, 116 (6), pp. 1219 - 1229
Abstract: Purpose To determine how immune markers are affected by acute hypoxic exercise at the same relative intensity. Methods Twelve endurance-trained males (age: 28 ± 4 years, V˙V˙ O2max: 63.7 ± 5.3 mL/kg/min) cycled for 75 min at 70 % of altitude-specific V˙V˙ O2max, once in normoxia (N) and once in hypobaric hypoxia equivalent to 2000 m above sea-level (H). Blood and saliva samples were collected pre-, post- and 2 h post-exercise. Results Participants cycled at 10.5 % lower power output in H vs. N, with no significant differences in heart rate (P = 0.10) or rating of perceived exertion (P = 0.21). Post-exercise plasma cortisol was higher in H vs. N [683 (95 % CI 576–810) nmol/l vs. 549 (469–643) nmol/l, P = 0.017]. The exercise-induced decrease in CD4:CD8 ratio was greater in H vs. N (−0.5 ± 0.2 vs. −0.3 ± 0.2, P = 0.019). There were no significant between-trial differences for adrenocorticotropic hormone, plasma cytokines, antigen-stimulated cytokine production, salivary immunoglobulin-A or lactoferrin. However, there was a main trial effect for concentration [F(11) = 5.99, P < 0.032] and secretion [F(11) = 5.01, P < 0.047] of salivary lysozyme, with this being higher in N at every time-point. Conclusion Whether the observed differences between H and N are of sufficient magnitude to clinically impair host defence is questionable, particularly as they are transient in nature and since other immune markers are unaffected. As such, acute hypoxic exercise likely does not pose a meaningful additional threat to immune function compared to exercise at sea level, provided that absolute workload is reduced in hypoxia so that relative exercise intensity is the same.
Description: This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Version: Published
DOI: 10.1007/s00421-016-3380-4
URI: https://dspace.lboro.ac.uk/2134/22252
Publisher Link: http://dx.doi.org/10.1007/s00421-016-3380-4
ISSN: 1439-6327
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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