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|Title: ||Asymmetric total synthesis of (-)-erogorgiaene and its C11 epimer and investigation of their antimycobacterial activity|
|Authors: ||Incerti-Pradillos, Celia A.|
Kabeshov, Mikhail A.
Shipilovskikh, Sergei A.
Rubtsov, Aleksandr E.
Drobkova, Vera A.
Balandina, Svetlana Yu
Malkov, Andrei V.
|Issue Date: ||2016|
|Publisher: ||© Wiley|
|Citation: ||INCERTI-PRADILLOS, C.A. ... et al, 2016. Asymmetric total synthesis of (-)-erogorgiaene and its C11 epimer and investigation of their antimycobacterial activity. Chemistry - A European Journal, 22 (40), pp. 14390-14396.|
|Abstract: ||A short, nine-step, highly enantioselective synthesis of (−)-erogorgiaene and its C-11 epimer is reported. The key stereochemistry controlling steps involve catalytic asymmetric crotylation, anionic oxy-Cope rearrangement and cationic cyclisation. (−)-Erogorgiaene exhibited promising antitubercular activity against multidrug-resistant strains of Mycobacterium tuberculosis.|
|Description: ||This paper is embargoed until August 2017.|
|Sponsor: ||The authors thank Russian Science Foundation for grant 15-13-00092 and the Loughborough University for studentships to CAIP and PSOH.|
|Version: ||Accepted for publication|
|Publisher Link: ||http://dx.doi.org/10.1002/chem.201602440|
|Appears in Collections:||Closed Access (Chemistry)|
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