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Title: In vivo biocompatibility and bioactivity of in situ synthesized hydroxyapatite/polyetheretherketone composite materials
Authors: Ma, Rui
Weng, Luqian
Bao, Xujin
Song, Shenhua
Zhang, Yu
Keywords: Hydroxyapatite
In-situ synthesis
In vivo bioactivity
Issue Date: 2013
Publisher: © Wiley Periodicals
Citation: MA, R. ... et al., 2013. In vivo biocompatibility and bioactivity of in situ synthesized hydroxyapatite/polyetheretherketone composite materials. Journal of Applied Polymer Science, 127 (4), pp.2581-2587.
Abstract: Hydroxyapatite/polyetheretherketone (HA/PEEK) composite materials were prepared via an in situ synthesis process in order to achieve strong bonding between PEEK matrix and hydroxyapatite fillers, and ultimately to improve the mechanical properties of the composites. In the study, the biocompatibility of the synthesized HA/PEEK materials was investigated by acute toxicity test, hemolytic test, sensitization test, pyrogen test, intradermal test, and toxicity assay test on animal tissue and cells for the purpose of examining the possible adverse effects of the residue organic chemicals from the in situ synthesis process. In vivo bioactivity of both lab-synthesized PEEK and HA/PEEK composites with various HA content was also studied. It is found that the in situ synthesized composite materials possess good biocompability without toxicity. Although the bioactivity of the material increases with HA content, the composite material with 5.6 vol % HA exhibits satisfactory bioactivity without compromising its excellent mechanical performance, which hints to a potential use as load-bearing orthopedic material.
Description: Closed access
Sponsor: This work was supported by the Technology Program of Nanshan district of Shenzhen in China.
Version: Published
DOI: 10.1002/app.37926
URI: https://dspace.lboro.ac.uk/2134/22414
Publisher Link: http://dx.doi.org/10.1002/app.37926
ISSN: 0021-8995
Appears in Collections:Closed Access (Materials)

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