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Title: Inflammation-mediating cytokine response to acute hand cycling exercise with/without functional electrical stimulation-evoked lower-limb cycling
Authors: Paulson, Thomas A.W.
Bishop, Nicolette
Smith, Brett M.
Goosey-Tolfrey, Victoria L.
Keywords: Anti-inflammatory
Cardiovascular disease
Physical activity
Skeletal muscle
Spinal cord injury
Stress hormones
Issue Date: 2014
Publisher: United States Department of Veterans Affairs
Citation: PAULSON, T. ... et al., 2014. Inflammation-mediating cytokine response to acute hand cycling exercise with/without functional electrical stimulation-evoked lower-limb cycling. Journal of Rehabilitation Research and Development, 51 (4), pp.645-654.
Abstract: This feasibility study compared the plasma inflammation-mediating cytokine response to an acute bout of handcycling (HC) with and without the addition of functional electrical stimulation (FES)-evoked lower-limb cycling. On two separate occasions, five recreationally active, community-based participants with motor complete paraplegia (thoracic 5-7) performed 30 min HC and hybrid exercise (HYB) at a fixed power output. Venous blood samples were collected at rest, immediately postexercise, 1 h postexercise (post+1) and 2 h postexercise (post+2). Plasma interleukin (IL)-6, IL-10, IL-1 receptor antagonist (IL-1ra), adrenaline, and cortisol concentrations were determined via enzyme-linked immunoassay. Plasma IL-6 concentrations were significantly (p < 0.04) elevated (~2.5-fold) at post+1 and post+2 in HYB only. A small (0.5-fold), nonsignificant (p > 0.05) increase in IL-6 was observed at post+1 in HC, with concentrations significantly higher in HYB at post+2 (p < 0.02). Plasma IL-1ra was unaffected in both trials. Although not reaching statistical significance (p = 0.15), a ~1-fold increase in IL-10 concentration was seen in HYB at post+2. In contrast, increases in adrenaline (p < 0.04) and cortisol (p = 0.08) were observed immediately postexercise in HC and HYB. Initial findings suggest paralyzed skeletal muscle releases IL-6 in response to FES-evoked contractions. HYB may provide a greater anti-inflammatory potential in individuals with a thoracic spinal cord injury compared with HC alone.
Sponsor: This material is based on work supported by resources from the Peter Harrison Centre for Disability Sport at Loughborough University, a grant from The Coca-Cola Foundation to support consumable costs, and sponsorship from the Standing Start charitable foundation to cover travel costs.
Version: Published
DOI: 10.1682/JRRD.2013.08.0184
URI: https://dspace.lboro.ac.uk/2134/22649
Publisher Link: http://dx.doi.org/10.1682/JRRD.2013.08.0184
ISSN: 0748-7711
Appears in Collections:Published Articles (Sport, Exercise and Health Sciences)

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